Τίτλος:
Nestin and CD34 expression in colorectal cancer predicts improved
overall survival
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background
Nestin, a class VI intermediate filament protein of the cytoskeleton,
and CD34, a transmembrane phosphoglycoprotein, are markers of progenitor
cells. This study aimed to evaluate their expression and clinical
significance in colorectal cancer.
Methods
A clinically annotated tissue microarray, including 599 patients with
colorectal cancer, was analyzed by immunohistochemistry. Furthermore,
nestin and CD34 correlations with HIF-1a and a panel of cytokines and
chemokines were assessed using quantitative reverse transcription PCR
and The Cancer Genome Atlas dataset.
Results
Expression of nestin and CD34 was observed only in the tumor stroma.
Patients displaying high expression of nestin and CD34 demonstrated
higher rates of T1 and T2 tumors (p = .020), lower vascular invasion (p
< .001) and improved 5-year overall survival (65%; 95% CI = 55-73 vs
45%; 95% CI = 37-53) after adjusting for clinicopathological
characteristics (HR: 0.67; 95% CI = 0.46-0.96). A moderate to strong
correlation (r = 0.37-0.78, p < .03) of nestin and CD34 was demonstrated
for the following markers; HIF-1 alpha, CD4, CD8, FOXP3, IRF1, GATA3,
CCL2, CCL3, CXCL12 and CCL21.
Conclusions
Combined expression of nestin and CD34 expression is associated with
better overall survival possibly by modulating a favorable immune
response.
Συγγραφείς:
Tampakis, Athanasios
Weixler, Benjamin
Rast, Silvan
Tampaki,
Ekaterini-Christina
Cremonesi, Eleonora
Kancherla, Venkatesh and
Tosti, Nadia
Kettelhack, Christoph
Ng, Charlotte K. Y. and
Delko, Tarik
Soysal, Savas D.
von Holzen, Urs
Felekouras,
Evangelos
Nikiteas, Nikolaos
Bolli, Martin
Tornillo, Luigi
and Terracciano, Luigi
Eppenberger-Castori, Serenella
Spagnoli,
Giulio C.
Piscuoglio, Salvatore
von Flue, Markus
Daster,
Silvio
Droeser, Raoul A.
Περιοδικό:
Acta Oncologica
Εκδότης:
TAYLOR & FRANCIS LTD LONDON
Λέξεις-κλειδιά:
Nestin; CD34; colorectal cancer; tumor microenvironment; hypoxia
associated immune response
DOI:
10.1080/0284186X.2021.1891280
