Τίτλος:
Association between childhood asthma and history of assisted
reproduction techniques: a systematic review and meta-analysis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Genetic and environmental factors during early development may influence
lung growth and impact lung function. We performed a meta-analysis of
epidemiological studies examining the association between conception
history of assisted reproduction techniques (ART) and childhood asthma.
We searched PubMed and Embase up to November 2020 for relevant
observational studies and synthesized data data under a fixed or random
effects model as appropriate. Heterogeneity was assessed using the I-2
metric. We identified 13 individual studies including 3,226,386
participants. We did not observe a statistically significant association
between ART and physician-diagnosed asthma (n = 9, random OR 1.16; 95%
CI 0.94-1.43; I-2 61%). We observed a statistically significant
association between ART and prescription of asthma medications (n = 6,
fixed OR 1.27; 95% CI 1.23-1.32; I-2 0%). Wheezing was also associated
with ART (n = 4, fixed OR 1.71; 95% CI 1.08-2.72; I-2 0%). When we
combined studies using any asthma definition, a statistically
significant association was observed (random OR 1.19; 95% CI 1.05-1.34;
I-2 80%).
Conclusion: The available observational evidence suggests that the risk
of asthma is higher among children born after ART. The mechanism and
potential sources of bias behind this association are under scrutiny,
and further work is needed to establish causality.
What is Known:
“Positive” epidemiological signals for the association between
assisted reproduction techniques and asthma stemming from large studies
were not replicated by subsequent research.
Any available research synthesis effort so far bears no quantitative
aspect.
What is New:
The available observational evidence suggests that the risk of asthma is
higher among children born after ART.
The mechanism and potential sources of bias behind this association are
under scrutiny.
Συγγραφείς:
Tsabouri, Sofia
Lavasidis, Georgios
Efstathiadou, Anthoula and
Papasavva, Margarita
Bellou, Vanessa
Bergantini, Helio and
Priftis, Konstantinos
Ntzani, Evangelia E.
Περιοδικό:
European Journal of Pediatrics
Λέξεις-κλειδιά:
Assisted reproduction techniques; Asthma; In vitro fertilization;
Wheezing; Meta-analysis; Systematic review
DOI:
10.1007/s00431-021-03975-7
