Τίτλος:
Association of systemic inflammatory biomarkers with morphological
characteristics of coronary atherosclerotic plaque by intravascular
optical coherence tomography
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Despite significant advances in preventive, medical, and interventional
management, coronary artery disease remains the leading cause of death
worldwide. We now know that in the majority of acute coronary syndromes,
a thrombotic event is triggered either by the rupture or erosion of the
so-called high-risk or `vulnerable' plaque. However, accurately
identifying the individual who is at significant risk of acute event
remains the holy grail of preventive cardiology. To better stratify an
individual's risk of developing and suffering a cardiovascular event,
biomarkers are needed that can accurately predict coronary events and,
if possible, monitor disease activity in response to medical or
interventional therapies. In order to be able to understand the
association of these biomarkers with the morphological substrate of
high-risk plaques, intravascular imaging modalities can provide
invaluable assistance. Novel imaging tools such as optical coherence
tomography (OCT) have not only helped in identifying atherosclerotic
plaque characteristics that are unstable but also in estimating global
plaque burden. In this study, we provide an overview of our current
knowledge of association of various inflammatory markers with
atherosclerotic plaque characteristics seen on OCT. (C) 2021 Hellenic
Society of Cardiology. Publishing services by Elsevier B.V.
Συγγραφείς:
Koganti, S.
Karanasos, A.
Regar, E.
Rakhit, R. D.
Περιοδικό:
Ελληνική καρδιολογική επιθεώρηση
Εκδότης:
HELLENIC CARDIOLOGICAL SOC
Λέξεις-κλειδιά:
Coronary artery disease; Biomarkers; Optical coherence tomography
DOI:
10.1016/j.hjc.2020.06.008
