Περίληψη:
Purpose: The Patient Neurotoxicity Questionnaire (PNQ) represents a
diagnostic tool concerning patients with chemotherapy-induced peripheral
neuropathy (CIPN). The application of such a tool in the Greek clinical
praxis requires validation.
Methods: Validation consists of three stages - translation, reverse
translation, and patient application. Hundred oncologic patients were
assessed by comparing the PNQ to the National Cancer Institute-Common
Terminology Criteria for Adverse Events (NCI-CTCAE) at the chemotherapy
onset and second, fourth, and sixth sessions. The diagnostic tool’s
specific requirements (compliance, validity, concordance, sensitivity,
specificity, reliability) were statistically evaluated.
Results: Differences between translated texts and between the reverse
translation and the original were considered negligible. At the second,
fourth, and sixth session compliance was 98%, 95%, and 93% while
Cronbach’s a was 0,57 0,69, and 0,81, respectively. Cohen’s weighted.
was 0,67 and 0,58, Spearman’s. was 0,7 and 0,98, while the area under
the curve (AUC) of the receiver operating characteristic (ROC) was 1 and
0,9 for the sensory and the motor part, respectively. The variance’s
linear regression analysis confirmed CIPN worsening over time
(P<0.0001).
Discussion: The Greek version remains close to the original English
version. Compliance rates reflect easy PNQ applications. Cohen’s. values
highlight the physicians’ tension to underestimate the patients’
condition. Spearman’s., Cronbach’s a, and AUC values reflect good
validity, reliability, and specificity of the PNQ respectively. Finally,
the linear analysis confirmed the PNQ sensitivity over time.
Conclusions: The PNQ validation in Greek adds a crucial tool to the
physicians’ armamentarium. It can now delineate the necessary
information to modify the chemotherapy and analgesic treatment regimens
at both preventive and acute levels.
Συγγραφείς:
Tsoleridis, Theofilos
Chloropoulou, Pelagia
Tsaroucha, Athanasia
and Vadalouca, Athina
Siafaka, Ioanna
Vogiatzaki, Theodosia
