Τίτλος:
Possible Roles of Vitamin D in Bone Grafting
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Bone grafting is one of the most commonly used options to treat large
bone defects. Evidence has shown that vitamin D may affect
osseointegration, a major component for successful bone grafting. In
vitro studies have proved that implants coated with activated vitamin D
stimulate bone production and reduce bone resorption around implants.
Animal studies have noticed that oral administration of vitamin D may
stimulate bone formation as well as strengthen and support the
interaction between bone and implants. Vitamin D insufficiency may
affect negatively the cortical peri-implant bone formation, suggesting a
negative effect in graft incorporation. Few clinical studies have
observed that vitamin D administration enhanced graft incorporation and
bone formation, while severe vitamin D deficiency is associated with
failed implant osseointegration. Even though there are encouraging
results of vitamin D supplementation on graft incorporation in animal
studies, the use of vitamin D as an adjuvant in bone grafting procedures
cannot be fully supported at the moment. However, there is theoretical
support in the use of vitamin D after surgery and the use of bone grafts
to support the bone structure, relieve pain and increase graft
absorption. Further experimental and clinical studies are required to
support the administration of vitamin D and its analogues in such cases.
Συγγραφείς:
Markopoulos, Georgios
Lepetsos, Panagiotis
Perrea, Despina N.
and Iliopoulos, Dimitrios C.
Nikolaou, Vasileios S.
Λέξεις-κλειδιά:
vitamin-d deficiency; vitamin-d; vitamin d supplementation; bone graft
substitutes; osseointegration
DOI:
10.7759/cureus.14688
