Περίληψη:
Contemporary developments in molecular biology have been combined with
discoveries on the analysis of the role of all non-coding RNAs (ncRNAs)
in human diseases, particularly in cancer, by examining their roles in
cells. Currently, included among these common types of cancer, are all
the lymphomas and lymphoid malignancies, which represent a diverse group
of neoplasms and malignant disorders. Initial data suggest that
non-coding RNAs, particularly long ncRNAs (lncRNAs), play key roles in
oncogenesis and that lncRNA-mediated biology is an important key pathway
to cancer progression. Other non-coding RNAs, termed microRNAs (miRNAs
or miRs), are very promising cancer molecular biomarkers. They can be
detected in tissues, cell lines, biopsy material and all biological
fluids, such as blood. With the number of well-characterized
cancer-related lncRNAs and miRNAs increasing, the study of the roles of
non-coding RNAs in cancer is bringing forth new hypotheses of the
biology of cancerous cells. For the first time, to the best of our
knowledge, the present review provides an up-to-date summary of the
recent literature referring to all diagnosed ncRNAs that mediate the
pathogenesis of all types of lymphomas and lymphoid malignancies.
Συγγραφείς:
Drillis, Georgios
Goulielmaki, Maria
Spandidos, Demetrios A. and
Aggelaki, Sofia
Zoumpourlis, Vassilios
