Τίτλος:
Regulatory and Functional Involvement of Long Non-Coding RNAs in DNA
Double-Strand Break Repair Mechanisms
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Protection of genome integrity is vital for all living organisms,
particularly when DNA double-strand breaks (DSBs) occur. Eukaryotes have
developed two main pathways, namely Non-Homologous End Joining (NHEJ)
and Homologous Recombination (HR), to repair DSBs. While most of the
current research is focused on the role of key protein players in the
functional regulation of DSB repair pathways, accumulating evidence has
uncovered a novel class of regulating factors termed non-coding RNAs.
Non-coding RNAs have been found to hold a pivotal role in the activation
of DSB repair mechanisms, thereby safeguarding genomic stability. In
particular, long non-coding RNAs (lncRNAs) have begun to emerge as new
players with vast therapeutic potential. This review summarizes
important advances in the field of lncRNAs, including characterization
of recently identified lncRNAs, and their implication in DSB repair
pathways in the context of tumorigenesis.
Συγγραφείς:
Papaspyropoulos, Angelos
Lagopati, Nefeli
Mourkioti, Ioanna and
Angelopoulou, Andriani
Kyriazis, Spyridon
Liontos, Michalis and
Gorgoulis, Vassilis
Kotsinas, Athanassios
Περιοδικό:
Cell Reports Medicine
Λέξεις-κλειδιά:
long non-coding RNAs; double-strand breaks (DSB); DNA damage response
and repair (DDRR); tumorigenesis
DOI:
10.3390/cells10061506
