Τίτλος:
Pulmonary adverse events due to immune checkpoint inhibitors: A literature review.
Περίληψη:
Cancer immunotherapy aims to stimulate the immune system to fight against tumors, utilizing the presentation of molecules on the surface of the malignant cells that can be recognized by the antibodies of the immune system. Immune checkpoint inhibitors, a type of cancer immunotherapy, are broadly used in different types of cancer, improving patients' survival and quality of life. However, treatment with these agents causes immune-related toxicities affecting many organs. The most frequent pulmonary adverse event is pneumonitis representing a non-infective inflammation localized to the interstitium and alveoli. Other lung toxicities include airway disease, pulmonary vasculitis, sarcoid-like reactions, infections, pleural effusions, pulmonary nodules, diaphragm myositis and allergic bronchopulmonary aspergillosis. This review aims to summarize these pulmonary adverse events, underlining the significance of an optimal expeditious diagnosis and management.
Συγγραφείς:
Georgakopoulou, Vasiliki Epameinondas
Garmpis, Nikolaos
Mermigkis, Dimitrios
Damaskos, Christos
Chlapoutakis, Serafeim
Mantzouranis, Konstantinos
Gkoufa, Aikaterini
Papageorgiou, Chrysovalantis
Garmpi, Anna
Makrodimitri, Sotiria
Diamantis, Evangelos
Sklapani, Pagona
Trakas, Nikolaos
Tsiafaki, Xanthi
Περιοδικό:
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace
DOI:
10.4081/monaldi.2021.2008
