Τίτλος:
A Role for Sox2 in the Adult Cerebellum.
Περίληψη:
The cerebellum, a derivative of the hindbrain, plays a crucial role in balance and posture as well as in higher cognitive and locomotive processes. Cerebellar development is initiated during the segmental phase of hindbrain formation. Here, we describe the phenotype, of a single surviving adult conditional mouse mutant mouse, in which Sox2 function is ablated in embryonic radial glial cells by means of hGFAP-CRE. The single Sox2(RGINV/mosaic) adult mutant mouse displays motor disability, microsomia, reduced Central Nervous System (CNS) size and cerebellar defects associated with human genetically related congenital abnormalities.
Συγγραφείς:
Mandalos, Nikolaos Panagiotis
Karampelas, Ioannis
Saridaki, Marannia
McKay, Ronald D. G.
Cohen, Mark L.
Remboutsika, Eumorphia
Περιοδικό:
Journal of stem cell research & therapy
Λέξεις-κλειδιά:
*Neurodegeneration, *Development, *Differentiation, *Neural progenitor cells, *Neural stem cells, *Neurogenesis, *Sox genes
DOI:
10.4172/2157-7633.1000433
