Τίτλος:
The Role of SNHG15 in the Pathogenesis of Hepatocellular Carcinoma
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Long non-coding RNAs (lncRNAs) are transcripts of more than 200 nucleotides which cannot be translated into proteins. Small nucleolar RNA host gene 15 (SNHG15) is a lncRNA whose dysregulation has been found to have an important impact on carcinogenesis and affect the prognosis of cancer patients in various cancer types. Hepatocellular carcinoma (HCC) is one of the most common cancers with a poor long-term prognosis, while the best prognostic factor of the disease is its early diagnosis and surgery. Consequently, the investigation of the mechanisms of hepatocarcinogenesis, as well as the discovery of efficient molecular markers and therapeutic targets are of great significance. An extensive literature search was performed in MEDLINE in order to identify clinical studies that tried to reveal the role of SNHG15 in HCC. We used keywords such as ‘HCC’, ‘hepatocellular carcinoma’, ‘SNHG15’ and ‘clinical study’. Finally, we included four studies written in English, published during the period 2016–2021. It was revealed that SNHG15 is related to the appearance of HCC via different routes and its over-expression affects the overall survival of the patients. More assays are required in order to clarify the potential role of SNHG15 as a prognostic tool and therapeutic target in HCC. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Damaskos, C.
Garmpis, N.
Dimitroulis, D.
Garmpi, A.
Diamantis, E.
Sarantis, P.
Georgakopoulou, V.E.
Patsouras, A.
Despotidis, M.
Prevezanos, D.
Syllaios, A.
Marinos, G.
Koustas, E.
Vallilas, C.
Antoniou, E.A.
Kontzoglou, K.
Savvanis, S.
Kouraklis, G.
Περιοδικό:
International Journal of Person-Centered Medicine
Λέξεις-κλειδιά:
long untranslated RNA; microRNA; small interfering RNA; transcription factor EZH2, angiogenesis; apoptosis; cancer prognosis; cancer survival; carcinogenesis; cell differentiation; cell invasion; cell proliferation; cell survival; cell viability; colony formation; disease free survival; down regulation; epithelial mesenchymal transition; gene; gene expression; genetic transfection; human; liver cell carcinoma; lung cancer; MAPK signaling; MTT assay; overall survival; pathogenesis; protein expression; Review; signal transduction; Small nucleolar RNA host gene 15; systematic review; tumor volume
