Τίτλος:
ALK Protein Expression Patterns in Squamous Cell Carcinoma of the Oral Cavity
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Oral squamous cell carcinoma (OSCC) is characterized by a broad spectrum of genomic imbalances, including gross chromosomal (polysomy/ aneuploidy) ones as well as specific gene alterations. Aberrant expression of anaplastic lymphoma kinase (ALK) seems to be a useful molecular marker for discriminating patients based on genetic signatures in a variety of solid malignancies, such as lung carcinoma. Our aim was to analyze ALK protein expression patterns in a series of OSCCs. Materials and Methods: Fifty (n=50) OSCC tissue sections were analyzed by implementing an ALK-based immunohistochemistry protocol. Digital image analysis was performed for measuring the corresponding protein expression levels. Results: ALK overexpression was observed in 14/50 (28%) OSCC tissue sections, whereas the rest 36/50 (72%) demonstrated low expression levels. ALK expression was negatively associated with grade (p=0.027) and stage (p=0.0028) of the examined cases. Conclusion: Abnormal ALK expression in subsets of patients with OSCC seems to be related to an aggressive phenotype (advanced stage/progressive dedifferentiation). ALK protein overexpression may be used as a significant marker for applying targeted therapeutic regimens. © 2022 International Institute of Anticancer Research. All rights reserved.
Συγγραφείς:
Chrysovergis, A.
Papanikolaou, V.
Mastronikolis, N.
Tsiambas, E.
Katsinis, S.
Manoli, A.
Papouliakos, S.
Ragos, V.
Pantos, P.
Peschos, D.
Mastronikolis, S.
Fotiades, P.
Mamoulidis, P.
Spyropoulou, D.
Kyrodimos, E.
Περιοδικό:
In vivo (Athens, Greece)
Εκδότης:
International Institute of Anticancer Research
Λέξεις-κλειδιά:
ALK protein, human; anaplastic lymphoma kinase; protein tyrosine kinase, genetics; human; mouth tumor; pathology; squamous cell carcinoma, Anaplastic Lymphoma Kinase; Carcinoma, Squamous Cell; Humans; Mouth Neoplasms; Receptor Protein-Tyrosine Kinases
DOI:
10.21873/invivo.12813
