Τίτλος:
Immunogenicity of the COVID-19 BNT162b2 vaccine in adolescents and young adults with cystic fibrosis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Data regarding immunogenicity of SARS-CoV-2 BNT162b2 vaccine in cystic fibrosis (CF) patients are limited. We prospectively measured total (TAbs-RBD; U/ml) and neutralizing (NAbs-RBD; %) antibodies of SARS-CoV-2 spike-receptor binding domain (RBD) protein in 33 CF patients and 66 healthy controls with median age (IQR): 19.6 (17.6–24.3) years and 31 (29–36) years, respectively and investigated possible associations with epidemiological and clinical parameters. Compared to healthy controls, CF patients had higher levels of TAbs-RBD and NAbs-RBD after both doses (P-value < 0.001). One month after the second dose, CF patients and controls had TAbs-RBD: median (IQR): 3396 (2443) and 1452 (1231) U/ml, respectively. Similarly, the NAbs-RBD (%) were: 97.30 (1.00) and 95.70 (3.71) %, respectively. CF patients also had fewer local and systemic adverse events (AEs) (P-value < 0.001). Among CF patients, no significant differences in immunogenicity were detected regarding the phenotype, genotype, medications, or severity of the disease. BNT162b2 vaccine was immunogenic with limited reactogenicity in CF patients regardless of the phenotype or severity of disease. © 2022
Συγγραφείς:
Michos, A.
Filippatos, F.
Tatsi, E.-B.
Dellis, C.
Efthymiou, V.
Zarkada, I.
Troupi, E.
Syriopoulou, V.
Loukou, I.
Περιοδικό:
Journal of Cystic Fibrosis
Λέξεις-κλειδιά:
antibiotic agent; azithromycin; ceftazidime; clindamycin; coronavirus spike glycoprotein; cystic fibrosis transmembrane conductance regulator; dornase alfa; ivacaftor; lumacaftor; minocycline; neutralizing antibody; SARS-CoV-2 antibody; tezacaftor; tozinameran; vaccine; virus antibody, adolescent; adult; antibody response; antibody titer; arthralgia; Article; blood sampling; body mass; cohort analysis; controlled study; coronavirus disease 2019; COVID-19 testing; cystic fibrosis; diabetes mellitus; drug hypersensitivity; edema; fatigue; female; fever; gene mutation; genotype; headache; health care personnel; homozygote; human; injection site pain; lymphadenopathy; major clinical study; male; myalgia; nonhuman; pancreatic insufficiency; pediatric hospital; phenotype; prospective study; Pseudomonas aeruginosa; Pseudomonas infection; Severe acute respiratory syndrome coronavirus 2; vaccination; vaccine immunogenicity; vaccinee; adverse event; cystic fibrosis; prevention and control; young adult, Adolescent; Antibodies, Viral; BNT162 Vaccine; COVID-19; COVID-19 Vaccines; Cystic Fibrosis; Humans; SARS-CoV-2; Vaccines; Young Adult
DOI:
10.1016/j.jcf.2022.04.004
