Περίληψη:
Endocan, previously called endothelial cell-specific molecule-1, is a soluble proteoglycan that is predominantly expressed in vascular endothelial cells of the lungs and kidneys. It is upregulated by proinflammatory cytokines and plays a critical role in inflammatory, proliferative, and neovascularization processes. The utility of endocan as a biomarker in a wide spectrum of diseases is being increasingly acknowledged. In this review, we summarize the current evidence concerning the role of endocan in kidney diseases, with emphasis on its prognostic and diagnostic value. It seems that the determination of plasma endocan levels may provide useful prognostic information in many types of renal failure such as chronic kidney disease, IgA nephropathy, and diabetic nephropathy. Endocan could additionally improve the early diagnostic evaluation of acute kidney disease, chronic renal allograft injury, and acute rejection after kidney transplantation, thus contributing to endothelial cell injury monitoring in a timely manner. © 2022 Elisabeth Samouilidou et al.
Συγγραφείς:
Samouilidou, E.
Athanasiadou, V.
Grapsa, E.
Λέξεις-κλειδιά:
endocan; proteoglycan; unclassified drug, acute graft rejection; acute kidney failure; cell damage; chronic allograft nephropathy; chronic kidney failure; diabetic nephropathy; diagnostic value; dialysis; endothelium cell; human; immunoglobulin A nephropathy; kidney disease; kidney polycystic disease; kidney transplantation; prognosis; protein expression; protein function; protein structure; Review
