Τίτλος:
Trained immunity in viral infections, Alzheimer's disease and multiple sclerosis: A convergence in type I interferon signalling and IFNβ-1a
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Type I interferon (IFN-I) signalling represents a major target for modulation in a virus' bid for latency. IFN-I perturbations are also present in such as Alzheimer's disease (AD) and multiple sclerosis (MS), where viral infections are known to increase symptomatic burden. IFN-I modulation such as via IFNβ-1a, an established MS treatment, has been researched to a limited extent to both AD and COVID-19. In this mini review, we present emerging research on trained immunity as a pathogenetic basis for Alzheimer's disease and the emerging context for IFNβ-1a repositioning, via mechanisms shared with multiple sclerosis and induced by viral infections. © 2022 Elsevier B.V.
Συγγραφείς:
Vavougios, G.D.
Mavridis, T.
Artemiadis, A.
Krogfelt, K.A.
Hadjigeorgiou, G.
Περιοδικό:
Biochimica et Biophysica Acta. Molecular Basis of Disease
DOI:
10.1016/j.bbadis.2022.166430
