Τίτλος:
QT interval extracted from 30-minute short resting Holter ECG recordings predicts mortality in heart failure
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Prolonged repolarization duration is a significant total mortality (TM) predictor in post-myocardial infarction patients. Aim: We examined the clinical significance of QT interval that was extracted from a Short Resting Holter ECG (SRH ECG – 30-min duration) as a TM predictor in heart failure (HF) patients. Methods: One hundred forty-five HF patients (male = 84%, mean age = 64 ± 12 years, mean LVEF = 33 ± 10%) underwent an SRH ECG recording for 30 min. These high-resolution ECG signals were analyzed and the QT interval was calculated and corrected according to the Fridericia formula. After 42.1 months, 26 patients died. Results: Univariate analysis for Deceased and Living groups: QTc:455 ± 33 ms vs 441 ± 32 ms (p = 0.04), LVEF:32 ± 10% vs 34 ± 9% (p < 0.5), Mean Heart Rate: 73 ± 11 bpm vs 69 ± 12 bpm (p = 0.2), SDNN/HRV: 45 ± 42 ms vs 41 ± 29 ms (p = 0.4), QRS: 123 ± 26 ms vs 119 ± 29 ms (p = 0.5). Multivariate Cox regression analysis with model adjusted for QTc, Mean Heart Rate, LVEF, QRS, revealed that QTc-Fridericia interval was an independent TM predictor (H.R.:1.017, 95% C.I.: 1.003–1.030, p = 0.01). The cut-off point of 490 ms (90th percentile) in the same model presented HR: 2.9 for TM (95%C.I.: 1.066–7.882, p = 0.03). Kaplan Meier curves depicted a clear difference in survival between the two patients' groups (QTc Group≥490 ms vs QTc Group <490 ms). The curve diverge was important (log-rank, p = 0.02). Conclusion: A fast risk stratification approach with SRH ECG recording is an efficient method for flash evaluation of mortality risk in HF patients. © 2022 Elsevier Inc.
Συγγραφείς:
Arsenos, P.
Gatzoulis, K.A.
Laina, A.
Doundoulakis, I.
Soulaidopoulos, S.
Kordalis, A.
Oikonomou, G.
Triantafyllou, K.
Fragakis, N.
Vasilikos, V.
Tsioufis, K.
Περιοδικό:
Journal of Electrocardiology
Λέξεις-κλειδιά:
adult; aged; Article; cardiovascular mortality; cardiovascular parameters; controlled study; female; heart failure; heart left ventricle ejection fraction; heart rate; heart rate variability; Holter monitoring; human; independent variable; major clinical study; male; middle aged; prediction; predictor variable; prospective study; QRS interval; QT interval; standard deviation of normal to normal; survival; ambulatory electrocardiography; electrocardiography; long QT syndrome; physiology; procedures; rest, Aged; Electrocardiography; Electrocardiography, Ambulatory; Heart Failure; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Rest
DOI:
10.1016/j.jelectrocard.2022.03.013
