Τίτλος:
Additive prognostic value of longitudinal myocardial deformation to SCORE2 in psoriasis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aims: Psoriasis has been associated with increased cardiovascular (CV) risk. We investigated whether markers of CV function and their change after treatment have a prognostic value for adverse outcomes. Methods and results: In a prospective study, at baseline and after 6 months of treatment with biological agents, we assessed in 298 psoriasis patients (i) left ventricular global longitudinal strain (GLS) and (ii) carotid-femoral pulse wave velocity (PWV), to evaluate their prognostic value for major adverse cardiovascular events (MACEs), including coronary artery disease, stroke, hospitalization for heart failure, and all-cause death over a 4-year follow-up period. During follow-up, 26 (8.7%) MACEs were recorded. By univariate analysis, decreasing absolute GLS values [hazard ratio (HR): 0.73, P < 0.001], decreasing GLS change after treatment (HR: 0.53, P = 0.008), and increasing PWV values (HR: 1.16, P = 0.049) were associated with adverse outcomes. Baseline GLS and its change post-Treatment remained independent predictors of adverse events after adjusting for several confounders (P < 0.05). The addition of baseline GLS and its absolute change post-Treatment to SCORE2 increased Harrell's C from 0.882 to 0.941. By multivariable analysis, for each 1% increase in absolute baseline GLS values, the risk of MACE decreased by 33% and for each 1% absolute increase of GLS post-Treatment compared with the baseline value, the risk of MACE decreased by 58%. Conclusion: Global longitudinal strain has an independent and additive prognostic value to SCORE2 for adverse CV events in psoriasis, providing timely decision-making for intensive anti-inflammatory treatment and aggressive modification of risk factors to reduce CV risk. © 2023 The Author(s). Published by Oxford University Press on behalf of the European Society of Cardiology.
Συγγραφείς:
Makavos, G.
Ikonomidis, I.
Lambadiari, V.
Koliou, G.-A.
Pavlidis, G.
Thymis, J.
Rafouli-Stergiou, P.
Kostelli, G.
Katogiannis, K.
Stamoulis, K.
Kountouri, A.
Korakas, E.
Theodoropoulos, K.
Frogoudaki, A.
Katsimbri, P.
Papadavid, E.
Περιοδικό:
European Heart Journal Open
Εκδότης:
Oxford University Press
DOI:
10.1093/ehjopen/oead016
