Περίληψη:
The human PROX1 gene (Prospero homeobox gene 1) is a member of the homeobox transcription factor family. PROX1 plays a key role in the development of the lymphatic system and is primarily used as a lymphatic vessel marker. However, as the accumulating evidence indicates that PROX1 is also implicated in the tumorigenesis of various cancer types, the scientific community has attempted to elucidate its complicated function in neoplasia pathogenesis, as well as its utility in cancer diagnosis, prognosis, and therapy. PROX1 has been shown to participate in the complex molecular mechanisms affecting tumorigenesis and has been associated with a plethora of clinicopatho-logical parameters, including tumor stage and patients’ overall survival. Depending on the specific organ affected, PROX1 has exhibited both tumor‐promoting and tumor‐suppressing properties, with its inhibition and reactivation representing possible novel therapeutic interventions, respec-tively. Moreover, researchers have reported PROX1 as a useful tool in the fields of diagnosis and prognosis assessment. The current study aims to summarize and present the existing data that ren-der PROX1 a novel and useful diagnostic and prognostic biomarker, as well as a possible therapeutic target. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Ntikoudi, E.
Pergaris, A.
Kykalos, S.
Politi, E.
Theocharis, S.
Λέξεις-κλειδιά:
bladder carcinoma; breast cancer; cancer diagnosis; cancer prognosis; cancer staging; cancer survival; cancer therapy; central nervous system tumor; colon cancer; esophagus cancer; female genital tract cancer; hepatobiliary system cancer; human; lung cancer; mouth cancer; neoplasm; overall survival; pancreas cancer; pathogenesis; prospero homeobox gene 1; protein expression; renal cell carcinoma; Review; soft tissue tumor; stomach cancer; thyroid cancer; tumor gene
