Τίτλος:
Association of serum levels of osteopontin and osteoprotegerin with adverse outcomes after endovascular revascularisation in peripheral artery disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Osteoprotegerin (OPG) and osteopontin (OPN) are vascular calcification inhibitors with a known role in the atherosclerotic and inflammatory process. We investigated their relationship with adverse outcomes (restenosis/adverse cardiovascular events) after endovascular revascularisation of patients with peripheral arterial disease (PAD). Methods: 203 consecutive patients were enrolled in the PAD group (PADG) and 78 age and sex-matched subjects with less than two cardiovascular risk factors served as control group (COG). PADG underwent standard medical assessment at baseline and 12 months after the procedure. During follow up major adverse cardiovascular events (MACEs) including arterial restenosis with need for reintervention were documented and the PADG was divided accordingly into two subgroups. Results: During 12-month follow-up, 82 MACE were recorded (MACE subgroup). The rest of 124 PAD patients remained free of MACE (non-MACE subgroup). At baseline, OPG (9.89 ± 2.85 ng/ml vs 3.47 ± 1.95 ng/ml, p < 0.001) and OPN (79.99 ± 38.29 ng/ml vs 35.21 ± 14.84 ng/ml, p < 0.001) levels were significantly higher in PADG compared to COG, as well as in MACE subgroup compared to non-MACE subgroup (13.29 ± 3.23 ng/ml vs 10.86 ± 3 ng/ml and 96.45 ± 40.12 ng/ml vs 78.1 ± 38.29 ng/ml, respectively). An independent association of PAD with OPG and OPN was found in the whole patient cohort. Although OPG and OPN were significantly related to MACE incidence in the univariate analysis, multiple logistic regression analysis failed to detect any independent predictor of MACE within the PADG. Conclusion: Baseline high OPG and OPN levels were independently associated with PAD presence. Even higher levels of those biomarkers were detected among PAD patients with MACE, however, their prognostic role should be further clarified. © 2022, The Author(s).
Συγγραφείς:
Kadoglou, N.P.E.
Kapetanios, D.
Korakas, E.
Valsami, G.
Tentolouris, N.
Papanas, N.
Lambadiari, V.
Karkos, C.
Περιοδικό:
Cardiovascular Diabetology
Εκδότης:
BioMed Central Ltd.
Λέξεις-κλειδιά:
osteopontin; osteoprotegerin; biological marker; osteopontin; osteoprotegerin, age; aged; Article; cardiovascular disease; cardiovascular risk factor; cohort analysis; controlled study; diastolic blood pressure; endovascular surgery; female; follow up; heart muscle ischemia; human; incidence; inflammation; intervention study; logistic regression analysis; major clinical study; male; medical assessment; peripheral occlusive artery disease; protein blood level; restenosis; systolic blood pressure; blood vessel calcification; peripheral occlusive artery disease; risk factor, Biomarkers; Humans; Osteopontin; Osteoprotegerin; Peripheral Arterial Disease; Risk Factors; Vascular Calcification
DOI:
10.1186/s12933-022-01605-6
