Τίτλος:
Saliva proteomics as fluid signature of inflammatory and immune‐mediated skin diseases
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Saliva is easy to access, non‐invasive and a useful source of information useful for the diagnosis of serval inflammatory and immune‐mediated diseases. Following the advent of genomic technologies and ‐omic research, studies based on saliva testing have rapidly increased and human salivary proteome has been partially characterized. As a proteomic protocol to analyze the whole saliva proteome is not currently available, the most common aim of the proteomic analysis is to discriminate between physiological and pathological conditions. The salivary proteome has been initially investigated in several diseases: oral squamous cell carcinoma and oral leukoplakia, chronic graft‐versus‐host disease, and Sjögren’s syndrome. Otherwise, salivary proteomics studies in the dermatological field are still in the initial phase, thus the aim of this review is to collect the best research evidence on the role of saliva proteomics analysis in immune‐mediated skin diseases to understand the direction of research in this field. The results of PRISMA analysis reported herein suggest that human saliva analysis could provide significant data for the diagnosis and prognosis of several immune‐mediated and inflammatory skin diseases in the next future. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Campanati, A.
Martina, E.
Diotallevi, F.
Radi, G.
Marani, A.
Sartini, D.
Emanuelli, M.
Kontochristopoulos, G.
Rigopoulos, D.
Gregoriou, S.
Offidani, A.
Περιοδικό:
International Journal of Molecular Sciences
Λέξεις-κλειδιά:
atopic dermatitis; bullous pemphigoid; human; immunopathology; inflammatory disease; lichen planus; pemphigus vulgaris; proteomics; psoriasis; randomized controlled trial (topic); Review; saliva analysis; skin disease; systematic review; vitiligo; early diagnosis; immunology; metabolism; procedures; prognosis; proteomics; saliva; skin disease, biological marker, Biomarkers; Early Diagnosis; Humans; Prognosis; Proteomics; Saliva; Skin Diseases
DOI:
10.3390/ijms22137018
