Τίτλος:
High-resolution NMR spectroscopy of the β-amyloid(1-28) fibril typical for Alzheimer's disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Unlabeled samples of the β-amyloid peptide(1-28) fibrils typical of Alzheimer's disease could be used to obtain well-resolved one- and two-dimensional 1H NMR spectra (see picture). The technique applied was high-resolution magic-angle spinning on a 600 MHz NMR spectrometer. The results are in agreement with a parallel, in-register arrangement of the β-amyloid peptide in the fibril.
Συγγραφείς:
Mikros, E.
Benaki, D.
Humpfer, E.
Spraul, M.
Loukas, S.
Stassinopoulou, C.I.
Pelecanou, M.
Περιοδικό:
Angewandte Chemie. International Edition
Λέξεις-κλειδιά:
Nuclear magnetic resonance spectroscopy, Fibrils, Diseases, amyloid beta protein, Alzheimer disease; article; beta sheet; nuclear magnetic resonance spectroscopy; nuclear Overhauser effect; protein analysis; protein assembly; protein structure; X ray crystallography
DOI:
10.1002/1521-3773(20011001)40:19<3603::AID-ANIE3603>3.0.CO;2-5
