Τίτλος:
Brief report: "Allergic symptoms" in children with autism spectrum disorders. more than meets the eye?
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Many children with Autism Spectrum Disorders (ASD) have either family and/or personal history of "allergic symptomatology", often in the absence of positive skin or RAST tests. These symptoms may suggest mast cell activation by non-allergic triggers. Moreover, children with mastocytosis or mast cell activation syndrome (MCAS), a spectrum of rare diseases characterized by increased number of activated mast cells in many organs, appear to have ASD at a rate tenfold higher (1/10 children) than that of the general population (1/100 children). Mast cell activation by allergic, infectious, environmental and stress-related triggers, especially perinatally, would release pro-inflammatory and neurotoxic molecules. We speculate these could disrupt the gut-blood-brain barriers, thus contributing to brain inflammation and ASD pathogenesis. Increased mast cell responsiveness may define at least a subgroup of ASD subjects, who could benefit from inhibition of mast cell activation. © 2011 Springer Science+Business Media, LLC.
Συγγραφείς:
Angelidou, A.
Alysandratos, K.-D.
Asadi, S.
Zhang, B.
Francis, K.
Vasiadi, M.
Kalogeromitros, D.
Theoharides, T.C.
Περιοδικό:
Journal of Autism and Developmental Disorders
Λέξεις-κλειδιά:
corticotropin releasing factor; immunoglobulin E; monocyte chemotactic protein 1; neurotensin; toll like receptor 3; toll like receptor 4; transforming growth factor beta1, adaptive immunity; allergy; article; asthma; atopic dermatitis; autism; blood brain barrier; cell activation; cell function; cerebrospinal fluid analysis; disease association; disease severity; encephalitis; environmental exposure; family history; food allergy; human; immune system; immunoglobulin blood level; infection; innate immunity; intestine; intestine mucosa permeability; mast cell; mastocytosis; neurotoxicity; nutritional intolerance; observational study; priority journal; protein binding; rhinitis; skin allergy; skin test; skin tingling; stress; urticaria; wheezing, Brain; Child; Child Development Disorders, Pervasive; Humans; Hypersensitivity; Mast Cells; Mastocytosis; Risk Factors
DOI:
10.1007/s10803-010-1171-z
