Τίτλος:
Short-term evaluation of liver tumors after transarterial chemoembolization: Limitations and feasibility of contrast-enhanced ultrasonography
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: To evaluate the limitations and the feasibility of contrast-enhanced ultrasonography (CEUS) for the assessment of tumor response shortly after transarterial chemoembolization (TACE). Materials and methods: Fifty seven patients (41 patients with hepatomas, 16 patients with metastases) were studied with CEUS before, 1 day after, and 30 days after TACE. A CEUS-efficiency score (CEUS-ES) was calculated, which evaluated: (a) the completeness of visualization of the target tumor(s) (2: good, 1: adequate, 0: poor) and (b) the quality of delineation of post-TACE necroses (2: good, 1: adequate, 0: poor). A CEUS study was considered as "diagnostic," if each of the aforementioned parameters was associated with grade 1 or 2. Results: CEUS studies were "diagnostic" in 36/57 patients (63.1%). Patients with hepatomas were more likely to undergo "diagnostic" CEUS than patients with metastases (70.7% vs. 43.7%, P = 0.0728). Lesions' multiplicity, deep location, hypoenhancement on pretreatment CEUS, and diffuse growth had a statistically significant (P < 0.05) negative impact on CEUS-ES. Hyperechogenicity on pre-treatment, unenhanced US had a non-statistically significant (P = 0.176) negative impact. Differences between "diagnostic" CEUS studies and CT/MR regarding detection of residual tumor were insignificant (P = 0.8178). Conclusion: The percentage of lesions which are unsuitable for post-TACE evaluation with CEUS is not negligible. For the rest, the respective role of CEUS is promising. © 2011 Springer Science+Business Media, LLC.
Συγγραφείς:
Moschouris, H.
Malagari, K.
Papadaki, M.G.
Kornezos, I.
Gkoutzios, P.
Tepelenis, N.
Matsaidonis, D.
Περιοδικό:
Abdominal Imaging
Λέξεις-κλειδιά:
doxorubicin, adult; aged; article; chemoembolization; computer assisted tomography; contrast enhancement; echography; female; human; liver cell carcinoma; liver metastasis; major clinical study; male; nuclear magnetic resonance imaging; priority journal; tumor growth, Adult; Aged; Aged, 80 and over; Chemoembolization, Therapeutic; Contrast Media; Feasibility Studies; Female; Humans; Liver Neoplasms; Male; Middle Aged; Phospholipids; Retrospective Studies; Sulfur Hexafluoride; Treatment Outcome
DOI:
10.1007/s00261-011-9690-4
