Περίληψη:
Background: Cardiopulmonary bypass (CPB) has been associated with activation and injury of endothelial cells, probably responsible for the systemic inflammatory response syndrome (SIRS) taking place in these patients. Methods: We measured plasma concentrations of soluble P-selectin (sP-s), E-selectin (sE-s), tetranectin (TN), vonWillebrand factor (vWF) levels, and angiotensin-converting enzyme (ACE) activity in 31 adult patients undergoing elective coronary artery bypass grafting, just before and up to three days after surgery, and in 25 healthy volunteers. Results: Patients showed higher plasma sP-s and sE-s and ACE concentrations, just before surgery, but significantly lower TN levels, compared with controls. During the first three postoperative days (PD), the concentration of each of the molecules followed a different and independent pattern, although in the third PD, the levels of sP-s, sE-s and ACE were higher and those of vWF and TN lower, compared with the preoperative ones. However, patients had higher sP-s (P=0.06), sE-s (P=0.07), and vWF (P=0.005), but lower TN concentrations (P=0.02) on the third PD compared with controls. Conclusions: CPB is characterised by pronounced changes in plasma sP-s, sE-s, TN, vWF levels, and ACE activity, which are associated with significant alteration in the intra- and early postoperative endothelial function observed in open heart surgery. © 2010 Wiley-Liss, Inc.
Συγγραφείς:
Panagiotopoulos, I.
Palatianos, G.
Michalopoulos, A.
Chatzigeorgiou, A.
Prapas, S.
Kamper, E.F.
Λέξεις-κλειδιά:
dipeptidyl carboxypeptidase; endothelial leukocyte adhesion molecule 1; PADGEM protein; tetranectin; von Willebrand factor; ACE protein, human; biological marker; dipeptidyl carboxypeptidase; lectin; selectin; tetranectin; von Willebrand factor, adult; aged; article; blood sampling; cardioplegia; clinical article; controlled study; coronary artery bypass graft; coronary artery recanalization; endothelium; enzyme activity; extracorporeal circulation; female; human; male; open heart surgery; operation duration; postoperative care; postoperative period; prospective study; protein blood level; blood; cardiopulmonary bypass; case control study; coronary artery bypass graft; middle aged; pathophysiology; systemic inflammatory response syndrome; time; vascular endothelium, Aged; Biological Markers; Cardiopulmonary Bypass; Case-Control Studies; Coronary Artery Bypass; Endothelium, Vascular; Female; Humans; Lectins, C-Type; Male; Middle Aged; Peptidyl-Dipeptidase A; Selectins; Systemic Inflammatory Response Syndrome; Time Factors; von Willebrand Factor
