Τίτλος:
The impact of obesity on the association between vitamin D deficiency and cardiovascular disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The aim of this article is to review the literature regarding the relationship between vitamin D deficiency and cardiovascular disease (CVD) and its modification in the presence of obesity. Despite the strong association between vitamin D status and cardiovascular outcomes, vitamin D supplementation trials in the general population have failed to decrease the incidence of cardiovascular events and mortality. A comprehensive study of the published literature and a comparison with experimental data lead to the conclusion that obesity, due to its high prevalence and strong association with both vitamin D deficiency and CVD, may act as a critical confounder, which is responsible for the different results on this association. Adoption of a vitamin D preventive supplementation strategy for CVD is unlikely to yield any benefit to the general population. However, it might be particularly useful in obese adults with increased risk for CVD. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Paschou, S.A.
Kosmopoulos, M.
Nikas, I.P.
Spartalis, M.
Kassi, E.
Goulis, D.G.
Lambrinoudaki, I.
Siasos, G.
Περιοδικό:
Nutrient Cycling in Agroecosystems
Λέξεις-κλειδιά:
reactive oxygen metabolite; vitamin D, Article; atherosclerosis; bioavailability; blood pressure regulation; body mass; cardiovascular disease; cardiovascular mortality; cardiovascular risk; diabetes mellitus; disease severity; follow up; human; hypercholesterolemia; hypertension; incidence; ischemic heart disease; obesity; oxidative stress; pathophysiology; prevalence; prospective study; randomized controlled trial (topic); risk factor; vasculitis; vitamin D deficiency; vitamin supplementation; cardiovascular disease; complication; vitamin D deficiency, Cardiovascular Diseases; Humans; Obesity; Vitamin D Deficiency
