Τίτλος:
Dietary patterns and non-alcoholic fatty liver disease in a Greek case–control study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: The aim of this study was to test the hypothesis that posteriori-derived dietary patterns of a Greek sample are associated with the odds for non-alcoholic fatty liver disease (NAFLD) and common NAFLD-related biomarkers. Methods: We recruited 351 individuals (134 NAFLD patients, 217 controls). NAFLD was diagnosed with abdominal ultrasound. Dietary intake data were collected through a semi-quantitative food frequency questionnaire of 172 items and dietary patterns were derived by factor analysis. Consumption of dietary patterns was divided into quartiles. Multivariate logistic and linear regression models were applied to investigate associations of dietary patterns with NAFLD odds and common NAFLD-associated biomarkers. Results: Four dietary patterns were identified. Adherence to the fast food–type dietary pattern was independently associated with higher odds for NAFLD. However, results were statistically significant only for the highest versus the lowest consumption (odds ratio, 3.9; P = 0.003). On the contrary, individuals in the second quartile of the unsaturated fatty acid dietary pattern had 55.7% reduced odds of developing NAFLD than those in the first quartile after adjusting for age, sex, energy intake, physical activity level, pack-years smoked, education years, and presence of metabolic syndrome (P = 0.039). The fast food–type pattern was further associated with higher levels of C-reactive protein and uric acid and the unsaturated fatty acid pattern with reduced levels of insulin and homeostatic model assessment of insulin resistance (P < 0.05). The prudent dietary pattern was associated with decreased triacylglycerol and uric acid levels (β = –5.960; P = 0.037 and β = –0.153; P = 0.035, respectively). Conclusion: This is the first study to indicate associations of dietary patterns with NAFLD in a European population. © 2018 Elsevier Inc.
Συγγραφείς:
P. Kalafati, I.
Borsa, D.
Dimitriou, M.
Revenas, K.
Kokkinos, A.
V. Dedoussis, G.
Περιοδικό:
Frontiers in Nutrition
Εκδότης:
ELSEVIER SCIENCE INC 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
Λέξεις-κλειδιά:
C reactive protein; insulin; triacylglycerol; unsaturated fatty acid; uric acid; C reactive protein; triacylglycerol; uric acid, adult; Article; case control study; controlled study; dietary compliance; dietary intake; dietary pattern; fast food; fat intake; female; Greece; homeostasis model assessment; human; major clinical study; male; nonalcoholic fatty liver; priority journal; risk factor; adverse event; blood; diet; feeding behavior; insulin resistance; middle aged; nonalcoholic fatty liver; odds ratio; principal component analysis, Adult; C-Reactive Protein; Case-Control Studies; Diet; Diet Surveys; Feeding Behavior; Female; Greece; Humans; Insulin Resistance; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Odds Ratio; Principal Component Analysis; Risk Factors; Triglycerides; Uric Acid
DOI:
10.1016/j.nut.2018.10.032
