Τίτλος:
Biocompatibility of resin composites subcutaneously implanted in rats with experimentally induced arthritis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: To evaluate the biocompatibility of resin composite specimens with different curing efficiency, subcutaneously implanted in rats with experimentally induced arthritis. Methods: The amount of remaining C{double bond, long}C bonds (%RDB) of hybrid resin composite specimens photopolymerized for 10 s and 40 s exposure time (n = 3) was measured by micro-attenuated total reflectance Fourier transform infrared spectroscopy. Male Wistar rats (n = 36) were classified in two groups (n = 18) of healthy animals and of animals with experimentally induced arthritis. Resin composite specimens irradiated for 10 s and 40 s and calcium hydroxide control specimens were implanted subcutaneously in each animals' dorsum. Following 2-, 4- and 9-week periods the animals were sacrificed. The development of arthritis was defined by biochemical analysis and the changes in the relative weight of animals' organs (spleen, thymus, adrenals). Tissue reactions were examined histologically. Results: %RDB per site and exposure time showed statistically significant differences. Lowest %RDB values were recorded on 40 s exposed specimens. Biochemical indices and relative organ weights demonstrated statistically significant differences between healthy animals and animals with arthritis. The health status of the animals and the materials used did not influence tissue response. First and second periods of sacrifice showed reduced propensity of connective tissue development in comparison to the third period. The same applied for the second period regarding the presence of giant cells. Significance: The materials tested and the animals' health status did not result in altered tissue response compared to control group. The period of sacrifice was associated with different tissue responses. © 2009 Academy of Dental Materials.
Συγγραφείς:
Anagnostou, M.
Chatzigianni, E.
Doucoudakis, S.
Potamianou, A.
Tesseromatis, C.
Περιοδικό:
DENTAL MATERIALS
Λέξεις-κλειδιά:
Attenuated total reflectance Fourier transform infrared spectroscopy; Biochemical analysis; Biochemical indices; Calcium hydroxides; Connective tissues; Control groups; Curing efficiency; Double bonds; Exposure-time; Giant cells; Health status; Implantation tests; Relative weights; Resin composites; Statistically significant difference; Tissue reactions; Tissue response; Wistar rat, Biocompatibility; Calcium; Fourier transform infrared spectroscopy; Hydrated lime; Musculoskeletal system; Rats; Resins; Spectroscopic analysis; Tissue, Animals, biomaterial; biomedical and dental materials; calcium hydroxide; carbon; resin; Spectrum composite resin, adrenal gland; animal; arthritis; article; chemistry; comparative study; connective tissue; drug effect; giant cell; infrared spectroscopy; male; materials testing; organ size; pathology; pathophysiology; photochemistry; randomization; rat; spleen; subcutaneous tissue; thymus; time; Wistar rat, Adrenal Glands; Animals; Arthritis, Experimental; Biocompatible Materials; Calcium Hydroxide; Carbon; Composite Resins; Connective Tissue; Dental Materials; Giant Cells; Male; Materials Testing; Organ Size; Photochemical Processes; Random Allocation; Rats; Rats, Wistar; Spectroscopy, Fourier Transform Infrared; Spleen; Subcutaneous Tissue; Thymus Gland; Time Factors
DOI:
10.1016/j.dental.2008.09.012
