Περίληψη:
Background: Intracranial ependymomas are the third most common primary brain tumor in children. In the present study, we set out to investigate the expression of p-53, p-27, bcl-2, epidermal growth factor receptor (EGFR) and of neuronal markers in pediatric supratentorial ependymomas, in correlation with Ki-67/MIB-1 proliferation index and prognosis. Materials and Methods: Nine children with supratentorial ependymomas that were treated surgically in our institute over the last seven years were identified and included in the study. The extent of resection was classified as gross total and subtotal, and was determined by MRI scans. The ependymal tumors were classified according to WHO classification. Results: Headache and seizures were the most common presenting symptoms and papilledema the most common sign. In seven cases, gross total excision was performed, and in two cases, the resection was subtotal. All ependymomas were anaplastic. Ki-67/MIB-1 was detected in 20-40% of the nuclei in all tumors. There was also increased expression of p-53, bcl-2, p-27, and EGFR. There was expression of neuronal markers in three cases. After a mean follow-up period of 32.1 months (range 16-74 months), eight children were alive. Five children suffered from tumor recurrence. Conclusions: Complete surgical excision should be the goal of surgery. The prognostic role of Ki-67, p-53, p-27, bcl-2, EGFR, and neuronal markers expression needs to be determined in multi-institutional studies due to tumor's rarity.
Συγγραφείς:
Alexiou, G.A.
Moschovi, M.
Stefanaki, K.
Panagopoulos, D.
Tsotra, M.
Siozos, G.
Sfakianos, G.
Prodromou, N.
Λέξεις-κλειδιά:
antineoplastic agent; biological marker; epidermal growth factor receptor; Ki 67 antigen; protein bcl 2; protein p27; protein p53, adolescent; article; brain surgery; brain tumor; cancer chemotherapy; cancer patient; cancer prognosis; cancer radiotherapy; cancer surgery; cell nucleus; child; childhood cancer; clinical article; disease duration; ependymoma; female; follow up; headache; hemiparesis; human; human cell; immunohistochemistry; infant; male; overall survival; papilledema; preschool child; progression free survival; protein expression; school child; seizure; simple partial seizure; supratentorial ependymoma; symptom; tumor localization; tumor recurrence; tumor volume; world health organization
