Possible COVID-19-Associated Pulmonary Aspergillosis due to Aspergillus niger in Greece

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:2999597 41 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Possible COVID-19-Associated Pulmonary Aspergillosis due to Aspergillus niger in Greece
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes direct damage to the pulmonary epithelium, enabling Aspergillus invasion. Rapid progression and high mortality of invasive aspergillosis have been reported. In the present study, we report a rare case of possible COVID-19-associated pulmonary aspergillosis (CAPA) caused by A. niger in a Greek patient. Diagnosis was based on ECMM/ISHAM specific criteria and the new algorithm “BM-AspICU” for the invasive pulmonary aspergillosis diagnostic strategy. The fungal isolate was recovered in a non-bronchoalveolar lavage (non-BAL) sample and its identification was performed by standard macroscopic and microscopic morphological studies. MALDI-TOF analysis confirmed the identification of A. niger. In addition, galactomannan antigen and Aspergillus real-time PCR testing were positive in the non-BAL sample, while in serum they proved negative. The A. niger isolate showed an MIC for fluconazole ≥128 µg/mL, for itraconazole and posaconazole 0.25 µg/mL, for voricona-zole 0.5 µg/mL, for flucytosine 4 µg/mL, for amphotericin B 1 µg/mL, and for all echinocandins (caspofungin, anidulafungin, micafungin) >8 µg/mL. The patient was initially treated with voricona-zole; amphotericin B was subsequently added, when a significant progression of cavitation was demonstrated on chest computed tomography. A. niger was not isolated in subsequent samples and the patient’s unfavorable outcome was attributed to septic shock caused by a pandrug-resistant Acinetobacter baumannii strain. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Έτος δημοσίευσης:
2022
Συγγραφείς:
Katsiari, M.
Mavroidi, A.
Palla, E.
Zourla, K.
Alonistiotis, T.
Ntorlis, K.
Nikolaou, C.
Vrioni, G.
Tsakris, A.
Περιοδικό:
Journal of Antibiotics
Εκδότης:
MDPI
Τόμος:
11
Αριθμός / τεύχος:
3
Επίσημο URL (Εκδότης):
DOI:
10.3390/antibiotics11030300
Το ψηφιακό υλικό του τεκμηρίου δεν είναι διαθέσιμο.