Περίληψη:
Aim The objective was to examine the prevalence of atherosclerotic cardiovascular disease (ASCVD) and its risk factors among patients with RA with diabetes mellitus (RA-DM) and patients with RA without diabetes mellitus (RAwoDM), and to evaluate lipid and blood pressure (BP) goal attainment in RA-DM and RAwoDM in primary and secondary prevention. Methods The cohort was derived from the Survey of Cardiovascular Disease Risk Factors in Patients with Rheumatoid Arthritis from 53 centres/19 countries/3 continents during 2014-2019. We evaluated the prevalence of cardiovascular disease (CVD) among RA-DM and RAwoDM. The study population was divided into those with and without ASCVD, and within these groups we compared risk factors and CVD preventive treatment between RA-DM and RAwoDM. Results The study population comprised of 10 543 patients with RA, of whom 1381 (13%) had DM. ASCVD was present in 26.7% in RA-DM compared with 11.6% RAwoDM (p<0.001). The proportion of patients with a diagnosis of hypertension, hyperlipidaemia and use of lipid-lowering or antihypertensive agents was higher among RA-DM than RAwoDM (p<0.001 for all). The majority of patients with ASCVD did not reach the lipid goal of low-density lipoprotein cholesterol <1.8 mmol/L. The lipid goal attainment was statistically and clinically significantly higher in RA-DM compared with RAwoDM both for patients with and without ASCVD. The systolic BP target of <140 mm Hg was reached by the majority of patients, and there were no statistically nor clinically significant differences in attainment of BP targets between RA-DM and RAwoDM. Conclusion CVD preventive medication use and prevalence of ASCVD were higher in RA-DM than in RAwoDM, and lipid goals were also more frequently obtained in RA-DM. Lessons may be learnt from CVD prevention programmes in DM to clinically benefit patients with RA. ©
Συγγραφείς:
Semb, A.G.
Rollefstad, S.
Ikdahl, E.
Wibetoe, G.
Sexton, J.
Crowson, C.
Van Riel, P.
Kitas, G.
Graham, I.
Rantapää-Dahlqvist, S.
Karpouzas, G.A.
Myasoedova, E.
Gonzalez-Gay, M.A.
Sfikakis, P.P.
Tektonidou, M.G.G.
Lazarini, A.
Vassilopoulos, D.
Kuriya, B.
Hitchon, C.
Stoenoiu, M.S.
Durez, P.
Pascual-Ramos, V.
Galarza-Delgado, D.A.
Faggiano, P.
Misra, D.P.
Borg, A.A.
Mu, R.
Mirrakhimov, E.M.
Gheta, D.
Douglas, K.
Agarwal, V.
Myasoedova, S.
Krougly, L.
Valentinovna Popkova, T.
TuchyÅ ová, A.
Tomcik, M.
Vrablik, M.
Lastuvka, J.
Horak, P.
Medkova, H.K.
Kerola, A.M.
Λέξεις-κλειδιά:
cardiovascular disease; complication; diabetes mellitus; human; rheumatoid arthritis; risk factor, Arthritis, Rheumatoid; Cardiovascular Diseases; Diabetes Mellitus; Heart Disease Risk Factors; Humans; Risk Factors
