Systemic autoimmune diseases, anti-rheumatic therapies, COVID-19 infection risk and patient outcomes

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:3000153 19 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Systemic autoimmune diseases, anti-rheumatic therapies, COVID-19 infection risk and patient outcomes
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
As of June 10th 2020 about 7.2 million individuals have tested positive for, and more than 410,000 have died due to COVID-19. In this review we outline the pathophysiology that underpins the potential use of anti-rheumatic therapies for severe COVID-19 infection and summarize the current evidence regarding the risk and outcome of COVID-19 in patients with systemic autoimmune diseases. Thus far there is no convincing evidence that any disease-modifying anti-rheumatic drug (conventional synthetic, biologic or targeted synthetic) including hydroxychloroquine, may protect against severe COVID-19 infection; answers about their possible usefulness in the management of the cytokine storm associated with severe COVID-9 infection will only arise from ongoing randomized controlled trials. Evidence on COVID-19 risk and outcome in patients with systemic autoimmune diseases is extremely limited; thus, any conclusions would be unsafe and should be seen with great caution. At present, the risk and severity (hospitalization, intensive care unit admission and death) of COVID-19 infection in people with autoimmune diseases do not appear particularly dissimilar to the general population, with the possible exception of hospitalization in patients exposed to high glucocorticoid doses. At this stage it is impossible to draw any conclusions for differences in COVID-19 risk and outcome between different autoimmune diseases and between the various immunomodulatory therapies used for them. More research in the field is obviously required, including as a minimum careful and systematic epidemiology and appropriately controlled clinical trials. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
Έτος δημοσίευσης:
2020
Συγγραφείς:
Kastritis, E.
Kitas, G.D.
Vassilopoulos, D.
Giannopoulos, G.
Dimopoulos, M.A.
Sfikakis, P.P.
Περιοδικό:
Rheumatology International
Εκδότης:
Springer-Verlag
Τόμος:
40
Αριθμός / τεύχος:
9
Σελίδες:
1353-1360
Λέξεις-κλειδιά:
biological product; disease modifying antirheumatic drug; glucocorticoid; hydroxychloroquine; antirheumatic agent; Janus kinase inhibitor; monoclonal antibody; tocilizumab; tumor necrosis factor inhibitor, autoimmune disease; coronavirus disease 2019; cytokine storm; death; disease severity; drug megadose; drug use; hospitalization; human; immunotherapy; infection risk; intensive care; pathophysiology; priority journal; Review; rheumatic disease; treatment outcome; autoimmune disease; Betacoronavirus; comorbidity; Coronavirus infection; cytokine release syndrome; immunology; pandemic; risk factor; severity of illness index; virus pneumonia, Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Autoimmune Diseases; Betacoronavirus; Comorbidity; Coronavirus Infections; Cytokine Release Syndrome; Humans; Janus Kinase Inhibitors; Pandemics; Pneumonia, Viral; Risk Factors; Severity of Illness Index; Tumor Necrosis Factor Inhibitors
Επίσημο URL (Εκδότης):
DOI:
10.1007/s00296-020-04629-x
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