Τίτλος:
Influenza burden, prevention, and treatment in asthma-A scoping review by the EAACI Influenza in asthma task force
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
To address uncertainties in the prevention and management of influenza in people with asthma, we performed a scoping review of the published literature on influenza burden; current vaccine recommendations; vaccination coverage; immunogenicity, efficacy, effectiveness, and safety of influenza vaccines; and the benefits of antiviral drugs in people with asthma. We found significant variation in the reported rates of influenza detection in individuals with acute asthma exacerbations making it unclear to what degree influenza causes exacerbations of underlying asthma. The strongest evidence of an association was seen in studies of children. Countries in the European Union currently recommend influenza vaccination of adults with asthma; however, coverage varied between regions. Coverage was lower among children with asthma. Limited data suggest that good seroprotection and seroconversion can be achieved in both children and adults with asthma and that vaccination confers a degree of protection against influenza illness and asthma-related morbidity to children with asthma. There were insufficient data to determine efficacy in adults. Overall, influenza vaccines appeared to be safe for people with asthma. We identify knowledge gaps and make recommendations on future research needs in relation to influenza in patients with asthma. © 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
Συγγραφείς:
Schwarze, J.
Openshaw, P.
Jha, A.
del Giacco, S.R.
Firinu, D.
Tsilochristou, O.
Roberts, G.
Selby, A.
Akdis, C.
Agache, I.
Custovic, A.
Heffler, E.
Pinna, G.
Khaitov, M.
Nikonova, A.
Papadopoulos, N.
Akhlaq, A.
Nurmatov, U.
Renz, H.
Sheikh, A.
Skevaki, C.
Περιοδικό:
Allergy: European Journal of Allergy and Clinical Immunology
Εκδότης:
Wiley-Blackwell Publishing Ltd
Λέξεις-κλειδιά:
influenza vaccine; antivirus agent; influenza vaccine, antiviral therapy; asthma; disease exacerbation; drug efficacy; drug safety; global disease burden; health care utilization; human; immunogenicity; influenza; influenza vaccination; morbidity; priority journal; prophylaxis; Review; seroconversion; virus load; asthma; complication; cost of illness; global health; health survey; immunology; influenza; meta analysis; outcome assessment; treatment outcome; vaccination; vaccine immunogenicity, Antiviral Agents; Asthma; Cost of Illness; Global Health; Humans; Immunogenicity, Vaccine; Influenza Vaccines; Influenza, Human; Patient Outcome Assessment; Public Health Surveillance; Treatment Outcome; Vaccination
