Τίτλος:
Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background Hazelnut allergy is birch pollen-driven in Northern/Western Europe and lipid transfer protein-driven in Spain and Italy. Little is known about other regions and other allergens. Objective Establishing a molecular map of hazelnut allergy across Europe. Methods In 12 European cities, subjects reporting reactions to hazelnut (n = 731) were evaluated and sensitization to 24 foods, 12 respiratory allergen sources, and latex was tested by using skin prick test and ImmunoCAP. A subset (124 of 731) underwent a double-blind placebo-controlled food challenge to hazelnut. Sera of 423 of 731 subjects were analyzed for IgE against 7 hazelnut allergens and cross-reactive carbohydrate determinants by ImmunoCAP. Results Hazelnut allergy was confirmed in 70% of those undergoing double-blind placebo-controlled food challenges. Birch pollen-driven hazelnut sensitization (Cor a 1) dominated in most cities, except in Reykjavik, Sofia, Athens, and Madrid, where reporting of hazelnut allergy was less frequent anyhow. In Athens, IgE against Cor a 8 dominated and strongly correlated with IgE against walnut, peach, and apple and against Chenopodium, plane tree, and mugwort pollen. Sensitization to seed storage proteins was observed in less than 10%, mainly in children, and correlated with IgE to nuts, seeds, and legumes. IgE to Cor a 12, observed in all cities (10% to 25%), correlated with IgE to nuts, seeds, and pollen. Conclusions In adulthood, the importance of hazelnut sensitization to storage proteins, oleosin (Cor a 12), and Cor a 8 is diluted by the increased role of birch pollen cross-reactivity with Cor a 1. Cor a 8 sensitization in the Mediterranean is probably driven by diet in combination with pollen exposure. Hazelnut oleosin sensitization is prevalent across Europe; however, the clinical relevance remains to be established. © 2015 American Academy of Allergy, Asthma & Immunology.
Συγγραφείς:
Datema, M.R.
Zuidmeer-Jongejan, L.
Asero, R.
Barreales, L.
Belohlavkova, S.
De Blay, F.
Bures, P.
Clausen, M.
Dubakiene, R.
Gislason, D.
Jedrzejczak-Czechowicz, M.
Kowalski, M.L.
Knulst, A.C.
Kralimarkova, T.
Le, T.-M.
Lovegrove, A.
Marsh, J.
Papadopoulos, N.G.
Popov, T.
Del Prado, N.
Purohit, A.
Reese, G.
Reig, I.
Seneviratne, S.L.
Sinaniotis, A.
Versteeg, S.A.
Vieths, S.
Zwinderman, A.H.
Mills, C.
Lidholm, J.
Hoffmann-Sommergruber, K.
Fernández-Rivas, M.
Ballmer-Weber, B.
Van Ree, R.
Περιοδικό:
Allergy: European Journal of Allergy and Clinical Immunology
Εκδότης:
Mosby Year Book Inc
Λέξεις-κλειδιά:
carbohydrate; food allergen; immunoglobulin E antibody; latex; oleosin; pollen antigen; seed storage protein; unclassified drug; allergen; carrier protein; Cor a 8 allergen, Corylus avellana; immunoglobulin E; lipid transfer protein; oleosin, Corylus avellana; plant antigen, adolescent; allergy rapid test; anaphylaxis; Article; birch; child; clinical evaluation; cross reaction; Europe; female; hazelnut allergy; human; major clinical study; male; nut allergy; outpatient department; prick test; priority journal; provocation test; sensitization; adult; blood; chemistry; double blind procedure; hazelnut; immunology; middle aged; molecular epidemiology; Nut Hypersensitivity; pathophysiology; pollen; skin test; statistics and numerical data, Adolescent; Adult; Allergens; Ambulatory Care Facilities; Antigens, Plant; Betula; Carrier Proteins; Corylus; Cross Reactions; Double-Blind Method; Europe; Female; Humans; Immunoglobulin E; Male; Middle Aged; Molecular Epidemiology; Nut Hypersensitivity; Pollen; Skin Tests
DOI:
10.1016/j.jaci.2014.12.1949
