Ερευνητικό υλικό ΕΚΠΑ

International Consensus for the Dosing of Corticosteroids in Childhood-Onset Systemic Lupus Erythematosus With Proliferative Lupus Nephritis

Αγγλικά

Objective: To develop a standardized steroid dosing regimen (SSR) for physicians treating childhood-onset systemic lupus erythematosus (SLE) complicated by lupus nephritis (LN), using consensus formation methodology. Methods: Parameters influencing corticosteroid (CS) dosing were identified (step 1). Data from children with proliferative LN were used to generate patient profiles (step 2). Physicians rated changes in renal and extrarenal childhood-onset SLE activity between 2 consecutive visits and proposed CS dosing (step 3). The SSR was developed using patient profile ratings (step 4), with refinements achieved in a physician focus group (step 5). A second type of patient profile describing the course of childhood-onset SLE for ≥4 months since kidney biopsy was rated to validate the SSR-recommended oral and intravenous (IV) CS dosages (step 6). Patient profile adjudication was based on majority ratings for both renal and extrarenal disease courses, and consensus level was set at 80%. Results: Degree of proteinuria, estimated glomerular filtration rate, changes in renal and extrarenal disease activity, and time since kidney biopsy influenced CS dosing (steps 1 and 2). Considering these parameters in 5,056 patient profile ratings from 103 raters, and renal and extrarenal course definitions, CS dosing rules of the SSR were developed (steps 3–5). Validation of the SSR for up to 6 months post–kidney biopsy was achieved with 1,838 patient profile ratings from 60 raters who achieved consensus for oral and IV CS dosage in accordance with the SSR (step 6). Conclusion: The SSR represents an international consensus on CS dosing for use in patients with childhood-onset SLE and proliferative LN. The SSR is anticipated to be used for clinical care and to standardize CS dosage during clinical trials. © 2021, American College of Rheumatology

2022

Chalhoub, N.E.
Wenderfer, S.E.
Levy, D.M.
Rouster-Stevens, K.
Aggarwal, A.
Savani, S.I.
Ruth, N.M.
Arkachaisri, T.
Qiu, T.
Merritt, A.
Onel, K.
Goilav, B.
Khubchandani, R.P.
Deng, J.
Fonseca, A.R.
Ardoin, S.P.
Ciurtin, C.
Kasapcopur, O.
Jelusic, M.
Huber, A.M.
Ozen, S.
Klein-Gitelman, M.S.
Appenzeller, S.
Cavalcanti, A.
Fotis, L.
Lim, S.C.
Silva, R.M.
Miramontes, J.R.
Rosenwasser, N.L.
Saad-Magalhaes, C.
Schonenberg-Meinema, D.
Scott, C.
Silva, C.A.
Enciso, S.
Terreri, M.T.
Torres-Jimenez, A.-R.
Trachana, M.
Al-Mayouf, S.M.
Devarajan, P.
Huang, B.
Brunner, H.I.
Abulaban, K.
Aguiar, C.
Ahn, S.-Y.
Akoghlanian, S.
Al-Abrawi, S.
Aljaberi, N.
Alperin, R.
Angeles-Han, S.
Ardalan, K.
Bader-Meunier, B.
Balboni, I.
Barbar-Smiley, F.
Baxter, S.
Beary, J.
Boneparth, A.
Brakeman, P.
Bridges, J.
Burgos-Vargas, R.
Cabral, D.A.
Cameto, J.
Carter, C.
Chang, J.
Chédeville, G.
Chhakchhuak, C.
Chiraseveenuprapund, P.
Cifuentes Alvarado, M.
Concannon, A.
Cooper, J.
Cron, R.
De Carvalho, L.M.
De Quattro, K.
De Ranieri, D.
Dizon, B.
Donnelly Wrigley, C.
Duong, M.D.
Eberhard, A.
Ede, K.
Edelheit, B.
Edens, C.
Espada, G.
Farhey, Y.
Flores, F.
Fritz, D.
Ganguli, S.
Gilbert, M.
Gittar, P.
Greenbaum, L.
Grom, A.
Gulati, G.
Harry, O.
Hayward, K.
Henrickson, M.
Hersh, A.
Hiraki, L.
Hiskey, M.
Hoffmann, S.
Hollander, M.
Hom, C.
Houk, L.
Houk, J.B.
Hsieh, E.W.Y.
Hsu, J.
Jensen, P.
Joos, R.
Jurado, R.
Jusan Fiorot, F.
Kallash, M.
Kamphuis, S.
Keltsev, V., (deceased)
Khanna, S.
Kim, S.
Kimseng, K.J.
Knight, A.
Kunder, R.
Lai, J.
Laskin, B.
Lewandowski, L.
Lim, L.
Linda, W.-W.
Lo, M.
Lovell, D.
Luggen, M.
Madison, J.
Mansuri, A.
Martin, L.
Mason, S.
Miller, M.
Mina, R.
Mohammed, A.
Moncrieffe, H.
Moorthy, L.
Morgan, E.
Mosquera, A.
Muntel, E.
Muscal, E.
Myones, B.
Nocton, J.
Ogbu, E.
Okamura, D.
Olson, J.
Orrock, J.
Paim-Marques, L.
Pain, C.
Park, C.
Patel, P.
Pereira, M.
Prado, R.D.
Radhakrishna, S.
Rheault, M.
Ridgway, W.
Riskalla, M.
Ronis, T.
Sadun, R.
Sagcal-Gironella, A.C.
Santos, M.C.
Schikler, K.
AL Suwairi, W.
Siddiqi, N.
Silva, M.F.
Singh-Grewal, D.
Smitherman, E.
Smolewska, E.
Son, M.B.
Srinivasalu, H.
Sule, S.
Susic, G.
Syed, R.
Thatayatikom, A.
Ting, T.
Toth, M.
Turnier, J.
Vashisht, P.
Vega Fernandez, P.
Velasquez, M.
von Scheven, E.
Wahezi, D.
Ware, A.
Wu, E.
Yan, J.
Yildirim-Toruner, C.
Zamparo, C.
Zhang, Y.
Lawson, E.
for the Childhood Arthritis
Rheumatology Research Alliance Lupus Nephritis Work Group
the Pediatric Rheumatology European Society Lupus Working Party

Arthritis and Rheumatology

John Wiley and Sons Inc

74

2

263-273

glucocorticoid, adolescent; child; complication; consensus development; female; human; lupus erythematosus nephritis; male; onset age; retrospective study; systemic lupus erythematosus, Adolescent; Age of Onset; Child; Female; Glucocorticoids; Humans; Lupus Erythematosus, Systemic; Lupus Nephritis; Male; Retrospective Studies

https://doi.org/10.1002/art.41930

10.1002/art.41930

https://pergamos.lib.uoa.gr/uoa/dl/object/3003153