Progesterone inhibits mast cell secretion

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:3004657 8 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Progesterone inhibits mast cell secretion
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Mast cells are involved in allergic reactions, where they secrete numerous vasoactive, inflammatory and nociceptive mediators in response to immunoglobulin E (IgE) and antigen. However, they have also been implicated in inflammatory conditions, such as painful bladder syndrome/interstitial cystitis (PBS/IC), irritable bowel syndrome (IBS) and migraines, all of which occur more often in women and are exacerbated during ovulation, but are suppressed during pregnancy. Mast cells express high affinity estrogen receptors and estradiol augments their secretion, while tamoxifen inhibits it. Here we report that progesterone (100 nM), but not the structurally related cholesterol, inhibits histamine secretion from purified rat peritoneal mast cells stimulated immunologically or by substance P (SP), an effect also documented by electron microscopy. These results suggest that mast cell secretion may be regulated by progesterone and may explain the reduced symptoms of certain inflammatory conditions during pregnancy. Copyright © by Biolife, s.a.s.
Έτος δημοσίευσης:
2006
Συγγραφείς:
Vasiadi, M.
Kempuraj, D.
Boucher, W.
Kalogeromitros, D.
Theoharides, T.C.
Περιοδικό:
International Journal of Immunopathology and Pharmacology
Εκδότης:
Biomedical Research Press s.a.s.
Τόμος:
19
Αριθμός / τεύχος:
4
Σελίδες:
787-794
Λέξεις-κλειδιά:
cholesterol; histamine; progesterone; substance P, animal cell; article; cell proliferation; cell stimulation; controlled study; dose response; drug inhibition; drug mechanism; electron microscopy; female; histamine release; male; nonhuman; peritoneum mast cell; priority journal; rat
Επίσημο URL (Εκδότης):
DOI:
10.1177/039463200601900408
Το ψηφιακό υλικό του τεκμηρίου δεν είναι διαθέσιμο.