Τίτλος:
Circulating resistin is a significant predictor of mortality independently from cardiovascular comorbidities in elderly, non-diabetic subjects with chronic kidney disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Context: Resistin is associated with inflammation, atherosclerosis and cardiovascular (CV) disease.Objective: To associate circulating resistin with all-cause and CV mortality in chronic kidney disease (CKD) patients.Methods: Serum resistin was determined in a cohort of 80 elderly, non-diabetic patients with stable CKD at different stages in a follow-up period of 5 years.Results: Circulating resistin was significantly elevated in deceased compared to alive patients. Resistin emerged as an independent biomarker of all-cause and CV mortality after a 5-year follow-up period.Conclusion: Elevated circulating resistin was a significant independent predictor of CV and all-cause mortality in elderly, non-diabetic CKD patients. © 2015 Taylor & Francis.
Συγγραφείς:
Marouga, A.
Dalamaga, M.
Kastania, A.N.
Kroupis, C.
Lagiou, M.
Saounatsou, K.
Dimas, K.
Vlahakos, D.V.
Περιοδικό:
Biomarker Insights
Εκδότης:
Taylor and Francis Ltd.
Λέξεις-κλειδιά:
adiponectin; C reactive protein; cystatin C; leptin; n(g),n(g) dimethylarginine; nicotinamide phosphoribosyltransferase; oxidized low density lipoprotein; resistin; thyrotropin; tumor necrosis factor alpha; biological marker; resistin; RETN protein, human, aged; Article; atherosclerosis; blood cell count; blood sampling; body mass; cardiac patient; cardiovascular mortality; chronic kidney disease; comorbidity; comparative study; diabetic patient; disease association; disease course; enzyme linked immunosorbent assay; female; follow up; geriatric patient; glomerulus filtration rate; heart rate; high performance liquid chromatography; homeostasis; human; laboratory test; major clinical study; male; prediction; smoking habit; survival rate; survivor; systolic blood pressure; thorax radiography; urinalysis; very elderly; blood; cardiovascular disease; chronic kidney failure; comorbidity; Kaplan Meier method; middle aged; mortality; prognosis; receiver operating characteristic, Aged; Biomarkers; Cardiovascular Diseases; Comorbidity; Female; Humans; Kaplan-Meier Estimate; Kidney Failure, Chronic; Male; Middle Aged; Prognosis; Resistin; ROC Curve
DOI:
10.3109/1354750X.2015.1118536
