Τίτλος:
Serum Bisphenol A concentrations in men with idiopathic infertility
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Bisphenol A (BPA) has been associated with male reproductive dysfunction. However, few studies have assessed BPA according to the cause of male infertility. Aim: To investigate serum BPA concentrations in infertile men according to infertility cause. Patients and methods: Men with infertility (n = 55) [non-obstructive azoospermia (n = 23), cryptorchidism (n = 12), varicocele (n = 20)] compared with fertile men (n = 25). Serum BPA concentrations were measured along with clinical and hormonal assessment. Results: BPA was detected in all men, with no difference between infertile and control groups [median (IQR) 0.19 (0.45) vs. 0.18 (0.28) ng/ml, p = 0.689] or among the infertility cause [azoospermia 0.30 (0.69), cryptorchidism 0.12 (0.39), varicocele 0.17 (0.23) ng/ml, p = 0.316]. High concentrations of BPA (>3 ng/ml) were observed only in infertile men. Α negative correlation was observed between ΒΡΑ concentrations and AMH (r = −0.320, p < 0.01). Conclusions: Although male infertility cannot be attributed to exposure to BPA, high concentrations of BPA could contribute to infertility. © 2019 Elsevier Ltd
Συγγραφείς:
Mantzouki, C.
Bliatka, D.
Iliadou, P.K.
Margeli, A.
Papassotiriou, I.
Mastorakos, G.
Kousta, E.
Goulis, D.G.
Περιοδικό:
Food and Chemical Toxicology
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
4,4' isopropylidenediphenol; Muellerian inhibiting factor; 4,4' isopropylidenediphenol; benzhydryl derivative; endocrine disruptor; Muellerian inhibiting factor; phenol derivative, adult; Article; azoospermia; blood analysis; case control study; causal attribution; clinical assessment; controlled study; cross-sectional study; cryptorchism; disease association; exposure; hormone blood level; hormone determination; human; idiopathic disease; major clinical study; male; men's health; sperm quality; spermatozoon abnormality; spermatozoon motility; varicocele; blood; male infertility; semen analysis, Adult; Anti-Mullerian Hormone; Benzhydryl Compounds; Endocrine Disruptors; Humans; Infertility, Male; Male; Phenols; Semen Analysis
DOI:
10.1016/j.fct.2019.02.016
