Τίτλος:
Cinnamon effects on blood pressure and metabolic profile: A double-blind, randomized, placebo-controlled trial in patients with stage 1 hypertension
Περίληψη:
Objective: Cinnamon effect on blood pressure remains controversial. The present pilot study assessed cinnamon effect on blood pressure, and metabolic profile of stage 1 hypertension patients (S1HTN). Materials and Methods: This double-blind placebo-controlled randomized trial was conducted between June and October 2019, in Mashhad, Iran. Study inclusion criteria comprised S1HTN diagnosis, based on 24-hour ambulatory blood pressure monitoring (ABPM). Subjects were randomly assigned to two groups: cinnamon group (capsule, 1500 mg/day, 90 days) and placebo group. On days 0 and 90, ABPM derived systolic and diastolic blood pressure (SBP and DBP, respectively), blood lipid profile, and fasting blood sugar (FBS) were recorded. Results: The two groups did not differ significantly regarding vascular risk factors, educational status, lipid profile and blood pressure at baseline, except for lower HDL-c in cinnamon group (p=0.03). On day 90, there was no significant difference between two study groups for lipid profile and blood pressure. A statistically significant decrease in mean 24-hr SBP and mean day SBP was observed in the cinnamon group, while mean night SBP and mean night DBP were decreased significantly in the placebo group after 90 days. A statistically significant decrease in mean change of day value of SBP was found in the cinnamon group, compared to the placebo. On day 90, FBS remained practically unchanged but a significant increase in HDL-c (5.8 unit; p=0.01) and a significant decrease in LDL-c levels (17.7 unit; p=0.009) were observed in the cinnamon group compared to placebo group. Conclusion: Cinnamon caused a statistically significant decrease in mean ambulatory SBP but in a clinically moderate way, and lipid profile was significantly improved. Therefore, cinnamon might be considered a complementary treatment in subjects with S1HTN. © 2021 Mashhad University of Medical Sciences. All rights reserved.
Συγγραφείς:
Shirzad, F.
Morovatdar, N.
Rezaee, R.
Tsarouhas, K.
Moghadam, A.A.
Λέξεις-κλειδιά:
cinnamon extract; glucose; high density lipoprotein cholesterol; low density lipoprotein cholesterol; placebo; triacylglycerol, adult; aged; Article; blood pressure; blood pressure monitoring; cardiovascular risk factor; cholesterol blood level; clinical article; controlled study; data analysis software; diastolic blood pressure; double blind procedure; drug effect; educational status; fasting; female; glucose blood level; human; hypertension; Iran; lipid fingerprinting; male; metabolism; night; pilot study; randomized controlled trial; systolic blood pressure; triacylglycerol blood level
