Τίτλος:
Effects of probiotics on diabetic nephropathy: A systematic review
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Diabetic Nephropathy is a frequent complication of diabetes mellitus due to functional and structural modifications in multiple kidney compartments. Probiotics have risen lately as a forthcoming therapeutic intervention but they have not been systematically evaluated in diabetic nephropathy so far. The aim of this systematic review was to evaluate randomized controlled trials and experimental studies assessing the effect of probiotic supplements on diabetic nephropathy. Methods: An extensive literature search was conducted through electronic databases (PubMed, Scopus, Cinahl and Medline) with the Medical Subject Headings and entry terms of “diabetic nephropathy”, “diabetic renal disease” and “probiotics”. The search yielded 116 results, 9 of which met the inclusion criteria for this systematic review. Results: Most of the microorganisms used in the studies belonged to the Lactobacillus and Bifidobacterium genus. The dosage ranged from 2×107 to 6×1010 CFU/ g. The form of the probiotics varied across the studies (capsules, sachets, soy milk, kefir and honey). The majority of the studies demonstrated the benefits of probiotic supplementation on the reduction of inflammation, oxidative stress and on the amelioration of renal function biomarkers in subjects with diabetic nephropathy. No major gastrointestinal adverse events were observed during the intervention time with probiotics. Conclusion: Findings of this systematic review demonstrate the positive impact of probiotics on Diabetic Nephropathy without any major adverse events. Moreover, future larger randomized controlled trials with bigger samples and longer follow-up time are deemed necessary for further valid results on the effectiveness of probiotic supplementation on Diabetic Nephropathy. © 2020 Bentham Science Publishers.
Συγγραφείς:
Vlachou, E.
Ntikoudi, A.
Govina, O.
Lavdaniti, M.
Kotsalas, N.
Tsartsalis, A.
Dimitriadis, G.
Περιοδικό:
Current Clinical Pharmacology
Εκδότης:
Bentham Science Publishers
Λέξεις-κλειδιά:
C reactive protein; creatinine; cystatin C; glucose; glutathione; glutathione peroxidase; glutathione reductase; high density lipoprotein cholesterol; insulin; interleukin 18; kefir; malonaldehyde; neutrophil gelatinase associated lipocalin; probiotic agent; progranulin; sialic acid; thiobarbituric acid reactive substance; triacylglycerol; tumor necrosis factor receptor 1; very low density lipoprotein, Article; bacterial strain; Bifidobacterium; colony forming unit; creatinine blood level; diabetic nephropathy; flatulence; glomerulus filtration rate; homeostasis model assessment; honey; human; inflammation; insulin blood level; kidney function; Lactobacillus; nonhuman; oxidative stress; priority journal; protein blood level; Quantitative Insulin Sensitivity Check Index; randomized controlled trial (topic); soybean milk; stomach disease; supplementation; systematic review; treatment duration; triacylglycerol blood level
DOI:
10.2174/1574884715666200303112753
