Περίληψη:
Although hypertension, hypercholesterolemia and diabetes mellitus (DM) are recognized as major cardio-metabolic risk factors in primary Acute Coronary Syndrome (ACS) prevention, studies focusing on secondary ACS incidence are scarce. In the present study, the association between the aforementioned factors and 10-year ACS prognosis was evaluated. From October 2003 to September 2004 2,172 consecutive patients with ACS diagnosis, from 6 Greek hospitals, were enrolled. During 2013-14, the 10-year follow-up was performed in 1,918 participants. Baseline clinical factors were assessed through physical examination, medical records and pharmacological management. All-cause mortality and the development of fatal or non-fatal ACS events were recorded through medical records or hospital registries. Logistic regression models were applied to evaluate the impact of baseline clinical status on the ACS prognosis. The 10-year all cause and ACS mortality rate was 32.6 and 17.8%, respectively. Multi-adjusted analysis highlighted that, after taking into account various potential confounders, DM was the sole clinical factor associated with adverse effect on the 10-year ACS fatal incidence [Odds Ratio (OR)=1.35, 95% Confidence Interval (95% CI) 1.01, 1.80, p=0.04]. DM was the only clinical factor that aggravated ACS prognosis, whereas abnormal lipids profile and blood pressure did not seem to determine prognosis. Thus, glycaemic control may play a critical role in the secondary CVD prevention management of ACS patients. © 2016 Bentham Science Publishers.
Συγγραφείς:
Notara, V.
Panagiotakos, D.B.
Michalopoulou, M.
Kouvari, M.
Tsompanaki, E.
Verdi, M.
Vassileiou, N.
Kalli, E.
Mantas, Y.
Kogias, Y.
Stravopodis, P.
Papanagnou, G.
Zombolos, S.
Pitsavos, C.
Antonoulas, Y.
Karanasios, A.
Rizos, L.
Mparmparoussis, M.
Kassimatis, G.
Giannopoulos, G.
Arapi, S.
Gialernios, T.
Massoura, C.
Sideris, S.
Daskalopoulos, N.
Stefanadis, C.
Papataxiarchis, E.
Tzanoglou, D.
Kouli, G.
Kouroupi, S.
Balli, M.
Vassileiou, N.
Tsomboli, V.
Chalamandaris, A.
for the GREECS Study Investigators
Λέξεις-κλειδιά:
antidiabetic agent; biochemical marker; cholesterol; creatine kinase; glucose; troponin I; glucose blood level, acute coronary syndrome; acute heart infarction; adult; aged; angioplasty; Article; bioethics; diabetes mellitus; electrocardiography; female; follow up; food frequency questionnaire; heart injury; heart muscle necrosis; human; hypercholesterolemia; hypertension; International Classification of Diseases; lifestyle; longitudinal study; major clinical study; male; mortality rate; obesity; observational study; physical activity; prognosis; risk factor; ST segment depression; ST segment elevation; unstable angina pectoris; acute coronary syndrome; complication; diabetes mellitus; glucose blood level; hospital mortality; hypercholesterolemia; hypertension; incidence; pathology; physiology; statistical model, Acute Coronary Syndrome; Aged; Blood Glucose; Diabetes Mellitus; Female; Hospital Mortality; Humans; Hypercholesterolemia; Hypertension; Incidence; Logistic Models; Longitudinal Studies; Male; Prognosis; Risk Factors
