Τίτλος:
Mepivacaine Alters Vascular Responsiveness to Vasoconstrictors in Aortic Rings from Normal and Aortic-Banded Rats
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The present study investigated the effects of mepivacaine on the response of rat aorta to vasoconstrictors in normal and aortic-banded animals. Cardiac hypertrophy was induced in Wistar rats by aortic banding, while shamoperated animals served as controls. Isolated aortic rings with or without endothelium were contracted with potassium chloride and phenylephrine in the presence of mepivacaine (10-3 M). Maximal tension was measured at the highest concentration of potassium chloride and phenylephrine. Maximal response to potassium chloride was reduced in the presence of mepivacaine both in normal and aortic-banded rings. As regards the vascular reactivity to phenylephrine, aortic rings with intact endothelium from aortic-banded rats have shown increased response as compared to normal. After mepivacaine administration this difference between normal and aortic-banded rats was abolished. In conclusion, in a model of cardiac hypertrophy such as that of aortic-banding, increased response to α1-adrenergic stimulation is observed, which is blunted by mepivacaine administration.
Συγγραφείς:
Mourouzis, C.
Pantos, C.
Mourouzis, I.
Saranteas, T.
Tesseromatis, C.
Kostopanagiotou, G.
Karageorgiou, C.
Varonos, D.
Cokkinos, D.
Περιοδικό:
BMC Pharmacology and Toxicology
Λέξεις-κλειδιά:
alpha 1 adrenergic receptor; mepivacaine; phenylephrine; potassium chloride; vasoconstrictor agent, animal model; animal tissue; aorta constriction; article; blood vessel reactivity; controlled study; drug activity; drug effect; heart ventricle hypertrophy; male; nonhuman; priority journal; rat; reduction; vascular endothelium; vascular ring; vasoconstriction; vasodilatation, Anesthetics, Local; Animals; Aorta; Cardiomegaly; Constriction; Endothelium, Vascular; Male; Mepivacaine; Muscle, Smooth, Vascular; Phenylephrine; Potassium Chloride; Rats; Rats, Wistar; Vasoconstrictor Agents, Animalia; Rattus norvegicus
DOI:
10.1111/j.1600-0773.2003.pto930604.x
