Περίληψη:
Seven sesquiterpene lactones, (-) sivasinolide (1), a new naturally occurring eudesmanolide (altissin, 2), desacetyl-β-cyclopyrethrosin (3), tatridin-A (4), 1-epi-tatridin B (5), 1α,10β-epoxy-6-hydroxy-1,10H-inunolide (6), and spiciformin (7), were isolated from Anthemis altissima. Also isolated were 10 known flavonoids, namely, apigenin (8), kaempferol 4′-methyl ether (9), quercetin (10), quercetin 3-methyl ether (11), isorhamnetin (12), rhamnetin (13), 6-hydroxyquercetin 3,6,4′-trimethyl ether (14), isoquercetrin (15), taxifolin (16), and eriodictyol (17), and one phenolic acid, chlorogenic acid (18). The structure and the stereochemistry of compound 2 were deduced by spectroscopic methods. The in vitro activity of the sesquiterpene lactones (1-5) against Helicobacter pylori, as well as against three Gram-positive and three Gram-negative bacteria growing aerobically, was tested using the microdilution method. Compounds 8-18 have also been tested against H. pylori.
Συγγραφείς:
Konstantinopoulou, M.
Karioti, A.
Skaltsas, S.
Skaltsa, H.
Λέξεις-κλειδιά:
1 epitatridin; 1alpha,10beta epoxy 6 hydroxy 1,10h inunolide; 6 hydroxyquercetin 3,6,4' trimethyl ether; altissin; apigenin; chlorogenic acid; deacetyl beta cyclopyrethrosin; eriodictyol; flavonoid; isoquercetrin; isorhamnetin; kaempferol 4' methyl ether; kaempferol derivative; phenol derivative; plant extract; quercetin; quercetin 3 methyl ether; rhamnetin; sesquiterpene lactone; sivasinolide; spiciformin; tatridin a; taxifolin; unclassified drug, Anthemis altissima; antibacterial activity; article; carbon nuclear magnetic resonance; drug isolation; drug structure; Gram negative bacterium; Gram positive bacterium; Helicobacter pylori; medicinal plant; minimum inhibitory concentration; nonhuman; phytochemistry; proton nuclear magnetic resonance; stereochemistry, Asteraceae; Gram-Negative Bacteria; Gram-Positive Bacteria; Greece; Helicobacter pylori; Lactones; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plants, Medicinal; Sesquiterpenes; Stereoisomerism, Anthemis altissima; Bacteria (microorganisms); Helicobacter pylori; Negibacteria; Posibacteria
