Ερευνητικό υλικό ΕΚΠΑ

Synthesis, cytotoxic activity, NMR study and stereochemical effects of some new pyrano[3,2-b]thioxanthen-6-ones and Pyrano[2,3-c]thioxanthen-7-ones

Αγγλικά

Some new substituted pyrano[3,2-b]thioxanthen-6-ones and pyrano[2,3-c]thioxanthen-7-ones were prepared and their cytotoxic activity was evaluated using acronycine as the reference compound. The conformation of the molecules was also investigated in an effort to correlate this parameter with the biological activity. Copyright © 2001 Elsevier Science Ltd.

2001

Kostakis, I.K.
Pouli, N.
Marakos, P.
Mikros, E.
Skaltsounis, A.-L.
Leonce, S.
Atassi, G.
Renard, P.

BIOORGANIC AND MEDICINAL CHEMISTRY

9

11

2793-2802

2 bromo 1,2 dihydro 1 hydroxy 6 methoxy 3,3 dimethyl 3h,7h pyrano[2,3 c]thioxanthen 7 one; acronine; cytotoxic agent; pyrano[2,3 c]thioxanthen 7 one derivative; pyrano[3,2 b]thioxanthen 6 one derivative; thioxanthene derivative; unclassified drug; 1 acetoxy 1,2 dihydro 6 methoxy 3,3 dimethyl 3h,7h pyran[2,3 c]thioxanthen 7 one; 1 acetoxy 2 bromo 1,2 dihydro 6 methoxy 3,3 dimethyl 3h,7h pyran[2,3 c]thioxanthen 7 one; 1,2 diacetoxy 1,2 dihydro 6 methoxy 3,3 dimethyl 3h,7h pyran[2,3 c]thioxanthen 7 one; 1,2 dihydro 1 hydroxy 6 methoxy 3,3 dimethyl 3h,7h pyran[2,3 c]thioxanthen 7 one; 1,2 dihydro 1,2 dihydroxy 6 methoxy 3,3 dimethyl 3h,7h pyran[2,3 c]thioxanthen 7 one; 2 bromo 1,2 dihydro 1 hydroxy 6 methoxy 3,3 dimethyl 3h,7h pyran[2,3 c]thioxanthen 7 one; 3 bromo 3,4 dihydro 4 hydroxy 5 methoxy 2,2 dimethyl 2h,6h pyran[3,2 b]thioxanthen 6 one; 3,4 diacetoxy 3,4 dihydro 5 methoxy 2,2 domethyl 2h.6h pyran[3,2 b]thioxanthen 6 one; 3,4 dihydro 3,4 dihydroxy 5 methoxy 2,2 dimethyl 2h,6h pyran[3,2 b]thioxanthen 6 one; 3,4 dihydro 4 hydroxy 5 methoxy 2,2 dimethyl 2h,6h pyran[3,2 b]thioxanthen 6 one; 4 acetoxy 3 bromo 3,4 dihydro 5 methoxy 2,2 dimethyl 2h,6h pyran[3,2 b]thioxanthen 6 one; 4 acetoxy 3,4 dihydro 5 methoxy 2,2 dimethyl 2h,6h pyran[3,2 b]thioxanthen 6 one; 5 methoxy 2,2 dimethyl 2h,6h pyran[3,2 b]thioxanthen 6 one; 6 methoxy 3,3 dimethyl 3h,7h pyran[2,3 c]thioxanthen 6 one; acronine; lucanthone; pyrano[2,3 c]thioxanthen 7 one derivative; pyrano[3,2 b]thioxanthen 6 one derivative; thioxanthene derivative, animal cell; article; controlled study; cytotoxicity; drug structure; drug synthesis; in vitro study; leukemia L 1210; nonhuman; stereochemistry; conformation; drug activity; drug cytotoxicity; drug effect; drug potency; leukemia cell; nuclear magnetic resonance; structure activity relation, Animals; Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Inhibitory Concentration 50; Ketones; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Molecular Conformation; Pyrans; Structure-Activity Relationship; Thioxanthenes; Tumor Cells, Cultured

https://doi.org/10.1016/S0968-0896(01)00130-4

10.1016/S0968-0896(01)00130-4

https://pergamos.lib.uoa.gr/uoa/dl/object/3023019