Τίτλος:
Does stress influence ampicillin concentration in serum and tissues?
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Exercise produces changes of drug levels in plasma and increases the concentration of free fatty acids (FFAs), which may interfere with drug-protein binding. FFAs seem to play an antagonistic role to drugs since they have a strong binding capacity to serum albumin. The aim of this study was to evaluate the influence of the consecutive exercise-induced stress in ampicillin levels. Two groups of Wistar rats were used. Group A consisted of six subgroups that were subjected to cold swimming (4°C) for 5, 10, 15, 20, 25, 30 days respectively. Group B was the control group. The animals were injected im. with ampicillin (1 g/Kg/8h in 5 doses). Results showed that exercise enhanced stress parameters (FFAs, adrenal weight, Ht%) and led to an ampicillin increase in all experimental groups comparatively to controls.
Συγγραφείς:
Tesseromatis, C.
Trichilis, A.
Tsivos, E.
Messari, J.
Triantaphyllidis, H.
Varonos, D.D.
Περιοδικό:
European Journal of Drug Metabolism and Pharmacokinetics
Εκδότης:
Editions Medecine et Hygiene
Λέξεις-κλειδιά:
albumin; ampicillin; fatty acid, adrenal gland; animal experiment; animal model; animal tissue; article; binding affinity; controlled study; dose response; drug binding; drug blood level; drug elimination; drug tissue level; exercise; male; nonhuman; organ weight; protein binding; rat; stress; swimming
