Τίτλος:
Synthesis of Novel Pyrazolo[3,4-b]pyridines with Affinity for β-Amyloid Plaques
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Three novel pyrazolo[3,4-b]pyridines were synthesized via the cyclization of 5-amino-1-phenylpyrazole with the corresponding unsaturated ketone in the catalytic presence of ZrCl4. The ketones were afforded by modifying a stabilized ylide facilitated Wittig reaction in fairly high yields. The novel compounds exhibited exciting photophysical properties with the dimethylamine phenyl-bearing pyrazolopyridine showing exceptionally large Stoke’s shifts. Finally, both the dimethylamino-and the pyrene-substituted compounds demonstrated high and selective binding to amyloid plaques of Alzheimer’s disease (AD) patient brain slices upon fluorescent confocal microscopy observation. These results reveal the potential application of pyrazolo[3,4-b]pyridines in the development of AD amyloid plaque probes of various modalities for AD diagnosis. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Vidali, V.P.
Nigianni, G.
Athanassopoulou, G.D.
Canko, A.
Mavroidi, B.
Matiadis, D.
Pelecanou, M.
Sagnou, M.
