Ερευνητικό υλικό ΕΚΠΑ

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Αγγλικά

In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10-8). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: Rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10-14), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10-10), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10-8), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10-8). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene. © 2018 The Author(s).

2018

Klein, A.P.
Wolpin, B.M.
Risch, H.A.
Stolzenberg-Solomon, R.Z.
Mocci, E.
Zhang, M.
Canzian, F.
Childs, E.J.
Hoskins, J.W.
Jermusyk, A.
Zhong, J.
Chen, F.
Albanes, D.
Andreotti, G.
Arslan, A.A.
Babic, A.
Bamlet, W.R.
Beane-Freeman, L.
Berndt, S.I.
Blackford, A.
Borges, M.
Borgida, A.
Bracci, P.M.
Brais, L.
Brennan, P.
Brenner, H.
Bueno-De-Mesquita, B.
Buring, J.
Campa, D.
Capurso, G.
Cavestro, G.M.
Chaffee, K.G.
Chung, C.C.
Cleary, S.
Cotterchio, M.
Dijk, F.
Duell, E.J.
Foretova, L.
Fuchs, C.
Funel, N.
Gallinger, S.
Gaziano, J.M.M.
Gazouli, M.
Giles, G.G.
Giovannucci, E.
Goggins, M.
Goodman, G.E.
Goodman, P.J.
Hackert, T.
Haiman, C.
Hartge, P.
Hasan, M.
Hegyi, P.
Helzlsouer, K.J.
Herman, J.
Holcatova, I.
Holly, E.A.
Hoover, R.
Hung, R.J.
Jacobs, E.J.
Jamroziak, K.
Janout, V.
Kaaks, R.
Khaw, K.-T.
Klein, E.A.
Kogevinas, M.
Kooperberg, C.
Kulke, M.H.
Kupcinskas, J.
Kurtz, R.J.
Laheru, D.
Landi, S.
Lawlor, R.T.
Lee, I.-M.
Lemarchand, L.
Lu, L.
Malats, N.
Mambrini, A.
Mannisto, S.
Milne, R.L.
Mohelníková-Duchoňová, B.
Neale, R.E.
Neoptolemos, J.P.
Oberg, A.L.
Olson, S.H.
Orlow, I.
Pasquali, C.
Patel, A.V.
Peters, U.
Pezzilli, R.
Porta, M.
Real, F.X.
Rothman, N.
Scelo, G.
Sesso, H.D.
Severi, G.
Shu, X.-O.
Silverman, D.
Smith, J.P.
Soucek, P.
Sund, M.
Talar-Wojnarowska, R.
Tavano, F.
Thornquist, M.D.
Tobias, G.S.
Van Den Eeden, S.K.
Vashist, Y.
Visvanathan, K.
Vodicka, P.
Wactawski-Wende, J.
Wang, Z.
Wentzensen, N.
White, E.
Yu, H.
Yu, K.
Zeleniuch-Jacquotte, A.
Zheng, W.
Kraft, P.
Li, D.
Chanock, S.
Obazee, O.
Petersen, G.M.
Amundadottir, L.T.

Nature Communications

Nature Publishing Group

9

1

ancestry; cancer; genome; identification method; meta-analysis, allele; Article; cancer genetics; cancer patient; case control study; cohort analysis; controlled study; expression quantitative trait locus; gene replication; genetic susceptibility; genome-wide association study; human; major clinical study; meta analysis (topic); pancreas cancer; genetic database; genetic predisposition; genetics; meta analysis; pancreas carcinoma; pancreas tumor; single nucleotide polymorphism, Europe; United States, hepatocyte nuclear factor 1beta; hepatocyte nuclear factor 4; HNF1B protein, human; HNF4G protein, human; NOC2L protein, human; protein; repressor protein; tensin; TNS3 protein, human; Ucma protein, human, Carcinoma, Pancreatic Ductal; Databases, Genetic; Genetic Predisposition to Disease; Genome-Wide Association Study; Hepatocyte Nuclear Factor 1-beta; Hepatocyte Nuclear Factor 4; Humans; Pancreatic Neoplasms; Polymorphism, Single Nucleotide; Proteins; Repressor Proteins; Tensins

https://doi.org/10.1038/s41467-018-02942-5

10.1038/s41467-018-02942-5

https://pergamos.lib.uoa.gr/uoa/dl/object/3026042