Τίτλος:
C reactive protein to albumin ratio (CAR) as predictor of anastomotic
leakage in colorectal surgery
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Anastomotic leakage (AL) is one of the most severe
complications in colorectal surgery. Currently, no predictive biomarkers
of AL are available. The aim of this study was to investigate the role
of C reactive protein (CRP) to albumin ratio (CAR) as a predictor of AL
in patients undergoing elective surgery for colorectal cancer. Materials
and Methods. Data on 1183 consecutive patients surgically treated for
histologically proven colorectal cancer in the surgical units involved
in the study were collected. Data included sex, age, BMI, ASA score,
Charlson comorbidity index, localization, histology and stage of the
disease, as well as blood tests including albumin and CRP at the 4th
postoperative day. Differences in CAR between patients who developed AL
and those who did not were analyzed, and the ability of CAR to predict
AL was investigated with ROC analysis. Results. CAR was significantly
higher in patients with AL in comparison to those without, at the 4th
postoperative day. In ROC analysis CAR showed a good ability in
detecting AL (AUC 0.825, 95%CI: 0,786-0,859), greater than those of CRP
and albumin alone. CAR also showed a high ability in detecting
postoperative deaths (AUC 0.750, 95% CI 0,956-0,987). These findings
were confirmed in multivariate analysis including the most relevant risk
factors for AL. Conclusion. Our study evidenced that CAR, an inexpensive
and widely available laboratory biomarker, adequately predicts AL and
death in patients who underwent elective surgery for colorectal cancer.
Συγγραφείς:
Paliogiannis, Panagiotis
Deidda, Simona
Maslyankov, Svilen and
Paycheva, Tsvetelina
Farag, Ahmed
Mashhour, Abdrabou and
Misiakos, Evangelos
Papakonstantinou, Dimitrios
Mik, Michal and
Losinska, Joanna
Scognamillo, Fabrizio
Sanna, Fabio
Feo,
Claudio Francesco
Porcu, Alberto
Xidas, Andreas
Zinellu,
Angelo
Restivo, Angelo
Zorcolo, Luigi
Περιοδικό:
SURGICAL ONCOLOGY-OXFORD
Εκδότης:
Elsevier Sci Ltd, Exeter, United Kingdom
Λέξεις-κλειδιά:
Cancer; Colorectal surgery; Anastomotic leakage; Biomarkers; CRP;
Albumin
DOI:
10.1016/j.suronc.2021.101621
