Τίτλος:
Irreversible Electroporation (IRE) Combined With Chemotherapy Increases
Survival in Locally Advanced Pancreatic Cancer (LAPC)
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objectives: Locally advanced pancreatic cancer (LAPC) is found in about
40% of patients with pancreatic cancer. Irreversible electroporation
(IRE) is a nonthermal ablative technique that provides an alternative in
patients with LAPC and can be safely combined with chemotherapy.
Materials and Methods: From 2015 until October of 2019, we performed
laparotomic IRE in a total of 40 patients with stage III LAPC. The
median age of these patients was 65.2 years (range: 46 to 81 y), and the
median tumor size was 3.8 cm (range: 2 to 5.2 cm). 33 of 40 patients
were treated preoperatively with FOLFIRINOX or nab-paclitaxel plus
gemcitabine and in case of disease control, IRE was performed, whereas
in 7 patients, IRE was performed without previous chemotherapy. Results:
All patients were treated successfully with IRE as the tumor evaluation
showed no disease progression after the completion of induction
chemotherapy. No IRE-related deaths occurred. Two major grade III
complications were reported: pancreatic fistula grade A in 8 patients
and 3 patients diagnosed with delayed gastric emptying. Up to October
31, 2019, the median overall survival (OS) of all patients was 24.2
months (range: 6 to 36 mo), and the median progression-free survival was
10.3 months (range: 3 to 24 mo). After the completion of IRE, 30
patients (75%) continued with adjuvant chemotherapy. Fifteen patients
(37%) have >24 months OS and 3 patients (8%) have reached 36 months OS
and are still alive. Conclusion: The combination of chemotherapy with
IRE, which is a safe and effective procedure, may result in a survival
benefit for patients with LAPC.
Συγγραφείς:
Oikonomou, Dimitrios
Karamouzis, Michalis V.
Moris, Dimitrios
and Dimitrokallis, Nikolaos
Papamichael, Demetris
Kountourakis,
Panteleimon
Astras, Georgios
Davakis, Spyridon
Papalampros,
Alexandros
Schizas, Dimitrios
Petrou, Athanasios S. and
Felekouras, Evangelos
Περιοδικό:
AMERICAN JOURNAL OF CLINICAL ONCOLOGY - CANCER CLINICAL TRIALS
Εκδότης:
Lippincott, Williams & Wilkins
Λέξεις-κλειδιά:
pancreatic cancer; LAPC; IRE; irreversible electroporation
DOI:
10.1097/COC.0000000000000826
