Τίτλος:
Clinical Genomic, phenotype and epigenetic insights into the pathology,
autoimmunity and weight management of patients with Myasthenia Gravis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Myasthenia Gravis (MG) is an autoimmune disease that affects
neuromuscular junctions and is characterized by muscle weakness as a
result of autoantibodies against certain proteins. As a heterogeneous
disorder, MG presents with different types, including neonatal, ocular
and generalized in both juveniles and adults. Different types of
antibodies serve a role in how MG presents. The main biological
characteristic of MG is the production of antibodies against the
muscular acetylcholine receptor; however, other types of antibody have
been associated with the disorder. The role of the thymus gland has been
established and thymectomy is a possible treatment of the disease, along
with traditional medication such as pyridostigmine bromide (Mestinon)
and immunosuppresants. In recent years, steps have been made towards
developing more sensitive diagnostic methods. Additionally, novel
treatments have demonstrated promising results. Developing new assays
may lead to an increased understanding of the disease and to unravelling
the genetic pathway that leads to the development of neuromuscular
diseases.
Συγγραφείς:
Golfinopoulou, Rebecca
Papageorgiou, Louis
Efthimiadou, Aspasia
and Bacopoulou, Flora
Chrousos, George
Eliopoulos, Elias and
Vlachakis, Dimitrios
Περιοδικό:
Molecular Medicine Reports
Εκδότης:
SPANDIDOS PUBL LTD
Λέξεις-κλειδιά:
autoimmunity; antibodies; thymus; human leukocyte antigen complex;
acetylcholine receptor; biological compounds; Myasthenia gravis with
thymus hyperplasia; weight; obesity
DOI:
10.3892/mmr.2021.12151
