Τίτλος:
SARS-CoV-2 seroepidemiological study in healthcare workers and
discordant results using seven different diagnostic methods
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The aim of the study was to access the SARS-CoV-2 antibody
seroprevalence in healthcare workers (HCWs) of a tertiary pediatric
hospital after the first wave of the pandemic and to compare the results
among seven commercially available antibody detection assays, including
chemiluminescence (CMIA), electroluminescence (ECLIA), Epsilon
nzyme-Linked Immunosorbent Assay (ELISA), and rapid immunochromatography
(RIC). SARS-CoV-2 antibody detection was performed in serum samples of
1216 HCWs, using a reference CMIA assay and 8/1216 (0.66%) were
detected positive. Positive serum samples were further tested with other
assays; however, only one sample was positive by all tests. The rest 7
cases were negative with ECLIA and ELISA and gave discordant results
with RIC test. Six months later, new serum samples of seropositive HCWs
were analyzed with the same 7 tests, with inconsistent results again.
Identification of reliable SARS-CoV-2 antibody tests is important to
determine the actual number of past infections, the duration of
antibodies, and guide public health decisions.
Συγγραφείς:
Tatsi, Elizabeth-Barbara
Dellis, Charilaos
Petridou, Evangelia
and Banou, Kirkira
Zachariadou, Levantia
Syriopoulou, Vassiliki
and Michos, Athanasios
Περιοδικό:
Healthcare Infection
Εκδότης:
Springer Berlin Heidelberg
Λέξεις-κλειδιά:
SARS-CoV-2; COVID-19; Serology; Antibody; Comparison; Immunity
DOI:
10.1007/s15010-021-01653-2
