Τίτλος:
Immunohistochemical Expression of FOXP3+Regulatory T Cells in
Proteinuric Primary Glomerulopathies
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
FOXP3+ regulatory T-cell (Tregs) detection in renal allograft biopsies
has been associated with a less intense immune response. Data about
FOXP3+ Tregs’ presence and role in primary glomerulopathies of native
kidneys are minimal. We comparatively studied the immunohistochemical
expression of FOXP3+ Tregs, CD4+ and CD3+ T cells in IgA nephropathy
(IgAN), focal segmental glomerulosclerosis (FSGS), and membranous
glomerulopathy (MGN). We retrospectively reviewed 71 renal biopsies (28
from patients with IgAN, 22 from patients with FSGS and 21 from patients
with MGN) performed with proteinuria as the main indication. FOXP3+
Tregs and CD4+ and CD3+ T cells in inflammatory cell infiltrates of the
interstitial tissue and periglomerular space were automatically counted
using image analysis software. Univariable and multivariable logistic
regressions were applied for statistical analysis. Nuclear FOXP3+
immunohistochemical expression was observed in T cells in 64% of IgAN
cases, 77% of FSGS cases, and 76% of MGN cases (p>0.05). Absolute
FOXP3+ Tregs count in the interstitial tissue was higher in patients
without arteriolar hyalinosis than in those with arteriolar hyalinosis
(1.814 +/- 2.160 vs. 831 +/- 696; p=0.029). In patients with a high
FOXP3+/CD4+ ratio in the interstitial tissue, the odds ratio for CKD-EPI
eGFR >= 60 ml/min/1.73 m(2) at biopsy was 4.80 (95% CI: 1.29-17.91;
p=0.019). FOXP3+ Tregs intrarenal infiltration in primary
glomerulopathies is common. FOXP3+ Tregs’ increased expression may be
associated with milder histological lesions. High FOXP3+/CD4+ ratio in
the interstitial tissue may have prognostic significance for renal
function preservation.
Συγγραφείς:
Vlachopanos, Georgios
Georgalis, Argyrios
Korkolopoulou,
Pinelopi
Patsouris, Efstratios
Gakiopoulou, Harikleia
Περιοδικό:
International Journal of Nephrology
DOI:
10.1155/2021/9961713
